ArticleCureus2025
Immunophenotypic Shift From CD8 to CD4 With Anaplastic Lymphoma Kinase (ALK)-Negative Anaplastic Large Cell Transformation in Mycosis Fungoides: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mycosis fungoides (MF) classically presents with a CD4+/CD8- immunophenotype at the time of diagnosis. MF may extremely rarely present with CD8+/CD4- and, even more rarely, may shift between CD4+ and CD8+ phenotypes. To date, very few phenotypic shifts in MF have been reported, and just two of them were in the CD8+ to CD4+ direction. Our case report describes another instance of CD8+ to CD4+ phenotypic shift of MF, but with associated transformation to anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) - the first documented case of its kind. We hope to spread awareness about such rare phenomena to guide future research.
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