Evidence map›Paper›PMID 40166781›Full record

ArticleCureus2025

The Sonographic Motion Quantification of the Third Ventricle Wall in Occlusive Hydrocephalus: A Dynamic Diagnostic Method.

Benjamin Würzer, Markus Radder, Jörn Pons-Kühnemann, Manfred Kaps, Florian C Roessler

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin WürzerDepartment of Neurology, Justus Liebig University, Giessen, DEU.
Markus RadderDepartment of Neurology, Justus Liebig University, Giessen, DEU.
Jörn Pons-KühnemannMedical Statistics, Institute of Medical Informatics, Justus Liebig University, Giessen, DEU.
Manfred KapsDepartment of Neurology, Justus Liebig University, Giessen, DEU.
Florian C RoesslerDepartment of Neurology, Justus Liebig University, Giessen, DEU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to devise a dynamic method to diagnose occlusive hydrocephalus by transcranial ultrasound. By using transcranial B-mode ultrasound and speckle tracking software, we registered cardiac-related pulsations of the lateral walls of the third ventricle. We determined the measurement location with the least variance in 24 participants using a mixed-effect model. In six patients, we used this optimized measuring procedure to obtain deformation curves before and after surgical therapy of occlusive (i.e., obstructive) internal hydrocephalus. Speckle tracking points at the lateral change of contrast delineating the wall of the third ventricle at the level of the thalami accounted for the least variance in normal subjects. Using this refined method, all normal participants showed transient lateral distension of the third ventricle. In all patients, the deformation curves before surgery clearly differed from the normal collective and showed mostly a transient reduction of ventricle diameter. In two hydrocephalus patients with operative restoration of normal cerebrospinal fluid (CSF) pathways, the curves after surgery resembled the normal collective. The complete remission of those changes in some patients suggested restoration of near-normal CSF dynamics.

Indexed as

b-mode ultrasoundcsf dynamicscsf fluid dynamicshydrocephalusobstructive hydrocephalusspeckle trackingthird ventricletranscranial ultrasound

Identifiers

PMID40166781
PMCPMC11956120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.