Evidence map›Paper›PMID 40166770›Full record

ArticleTrauma surgery & acute care open2025

Resuscitative Endovascular Balloon Occlusion of the Aorta in surgical and trauma patients: a systematic review, meta-analysis and practice management guideline from the Eastern Association for the Surgery of Trauma.

Melike N Harfouche, Nikolay Bugaev, John J Como, Douglas R Fraser, Allison G McNickle, Guy Golani, Benjamin P Johnson, Horacio Hojman, Hiba Abdel-Aziz, Jaswin S Sawhney and 6 more

Abstract read
In one paragraph

Article in Trauma surgery & acute care open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Assessing the role of REBOA in the management of hemodynamically unstable pelvic fractures: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Pooled it
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  9. Resuscitative endovascular balloon occlusion of the aorta in trauma patients: Past, present, and future.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Melike N HarfoucheDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9555-5698
Nikolay BugaevDivision of Trauma & Acute Care Surgery, Tufts Medical Center, Boston, Massachusetts, USA.ORCID 0000-0001-6325-6837
John J ComoDepartment of Surgery, MetroHealth Medical Center, Cleveland, Ohio, USA.
Douglas R FraserDivision of Trauma & Acute Care Surgery, MemorialCare Long Beach Medical Center, Long Beach, California, USA.
Allison G McNickleDepartment of Surgery, UNLV School of Medicine, Las Vegas, Nevada, USA.ORCID 0000-0002-2400-8440
Guy GolaniDepartment of General Surgery & Trauma Unit, Soroka Medical Center, Be'er Sheva, South District, Israel.
Benjamin P JohnsonDivision of Trauma & Acute Care Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Horacio HojmanDivision of Trauma & Acute Care Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Hiba Abdel-AzizWeill Cornell Medicine-Qatar, Doha, Qatar.
Jaswin S SawhneyDepartment of Surgery, Maine Medical Center, Portland, Maine, USA.
Daniel C CullinaneDepartment of Surgery, Maine Medical Center, Portland, Maine, USA.
Steven LorchDivision of Acute Care Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Elliott R HautDepartment of Surgery, Johns Hopkins Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7075-771X
Nicole FoxDepartment of Surgery, Cooper University Hospital, Camden, New Jersey, USA.ORCID 0000-0002-3381-716X
Laurence S MagderDepartment of Epidemiology & Public Health, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
George KasotakisDivision of Trauma & Acute Care Surgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-7630-0742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in the management of patients with subdiaphragmatic bleeding, as well as its utility in traumatic cardiac arrest (TCA), is unknown. Methods: A working group from the Eastern Association for the Surgery of Trauma (EAST) applied the Grading of Recommendations Assessment, Development and Evaluation methodology (GRADE) to perform a systematic review and meta-analysis, assess the level of evidence, and create recommendations pertaining to the use of REBOA in the management of trauma or non-trauma patients, as well as those in TCA (1946 to 2024). Results: Thirty-one studies were included in the meta-analysis. In unstable trauma patients with subdiaphragmatic bleeding, there was no significant difference in mortality among patients who were treated with REBOA vs no REBOA [OR 0.86, 95% CI 0.37, 2.04]. Subgroup analysis for individuals with pelvic fractures demonstrated higher mortality for REBOA vs no REBOA [OR=2.15, CI 1.35, 3.42]. In patients with TCA, pooled analysis demonstrated decreased mortality with REBOA vs resuscitative thoracotomy (OR 0.32, 95% CI 0.15, 0.69). Compared with no REBOA, prophylactic placement of REBOA prior to cesarean section in placenta accreta syndrome (PAS) had lower intra-operative blood loss [-1.06 L, CI -1.57 to -0.56] and red blood cell transfusion [-2.44 units, CI -4.27 to -0.62]. Overall, the level of evidence was assessed by the working group as very low. Conclusion: Considering the risks associated with its use and lack of discernible benefit, the committee conditionally recommends against the use of REBOA in trauma patients who are hemodynamically unstable due to suspected subdiaphragmatic hemorrhage. Further research is needed to identify specific subpopulations who may benefit. For individuals with TCA due to suspected subdiaphragmatic bleeding and for prophylactic placement in PAS, the committee conditionally recommends for the use of REBOA. Level of Evidence: IV.

Indexed as

Emergency TreatmentguidelineresuscitationShock, Hemorrhagic

Identifiers

PMID40166770
PMCPMC11956280

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.