Evidence map›Paper›PMID 40166590›Full record

ArticleTherapeutic advances in gastroenterology2025

Standardized approach to removal of lumen apposing metal stents following endoscopic necrosectomy: one size does not fit all.

Robert Dorrell, Alexa Cecil, Swati Pawa, Gregory Russell, Rishi Pawa

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert DorrellSection on Gastroenterology, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Alexa CecilDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Swati PawaSection on Gastroenterology, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Gregory RussellBiostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Rishi PawaDivision of Gastroenterology, Department of Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.ORCID https://orcid.org/0000-0001-6452-2359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Walled-off necrosis (WON) is a sequela of acute necrotizing pancreatitis preferentially managed with lumen apposing metal stents (LAMS). Adverse events including buried stent syndrome and bleeding have been associated with a longer duration of LAMS placement. Objectives: We attempt to examine our outcomes of a standardized approach to LAMS dwell time and hypothesize that LAMS removal based on imaging characteristics and patient symptoms improves outcomes. Design: From November 2015 to May 2022, a prospectively maintained database on patients with symptomatic WON undergoing endoscopic drainage with LAMS was retrospectively reviewed and analyzed. Methods: Patient characteristics, procedure details, and outcomes were recorded. Imaging was performed at 1, 3, and 6 weeks after LAMS placement and 1 week after each necrosectomy. Imaging findings and patient symptoms were used to determine the need for repeat necrosectomy. The timing of LAMS removal was guided by adequate endoscopic necrosectomy and resolution of the patient's symptoms. Subgroups were identified based on the duration of LAMS placement (less than 4 weeks and more than 4 weeks). Independent Results: In all, 104 patients underwent endoscopic necrosectomy during the study period. Of the two subgroups identified based on LAMS dwell time, 70 patients had a LAMS duration greater than 4 weeks and 34 patients had a LAMS duration less than 4 weeks. Collections with >50% necrosis were more commonly seen in patients with longer LAMS dwell time (<4 weeks (12%) vs >4 weeks (33%), Conclusion: A patient-specific customized approach to endoscopic drainage of WON improves outcomes. Patients with extensive necrosis may require a longer LAMS dwell time to achieve adequate debridement and clinical resolution. An increased risk of bleeding or adverse events related to prolonged duration of LAMS placement was not observed in our study. Future larger prospective studies are needed to confirm these conclusions.

Indexed as

endoscopic ultrasonographypancreatic necrosisself-expandable metallic stents

Identifiers

PMID40166590
PMCPMC11956515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.