ArticlemedRxiv : the preprint server for health sciences2025
Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities.
Bryan R Gorman, Jaxon J Huang, Peter B Barr, Christopher W Halladay, Cari L Nealon, Chris Chatzinakos, Michael Francis, Chen Jiang, Million Veteran Program, Paul B Greenberg and 7 more
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Bryan R GormanCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, 150 S Huntington Avenue, Boston, MA, 02130, USA.ORCID 0000-0002-4239-4672 Jaxon J HuangSurgical and Research Services, Miami Veterans Administration Medical Center, 1201 NW 16th Street, Miami, FL, 33125, USA.
Christopher W HalladayCenter of Innovation in Long Term Services and Supports, Providence VA Medical Center, 830 Chalkstone Avenue, Providence, RI, 02908, USA.
Cari L NealonEye Clinic, VA Northeast Ohio Healthcare System, 10701 East Boulevard, Cleveland, OH, 44106, USA.
Chris ChatzinakosDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA.ORCID 0000-0003-0557-9501 Michael FrancisCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, 150 S Huntington Avenue, Boston, MA, 02130, USA.ORCID 0000-0002-1320-7161 Chen JiangDivision of Research, Kaiser Permanente Northern California (KPNC), 4480 Hacienda Drive, Pleasanton, CA, 94588, USA.
Million Veteran Program
Paul B GreenbergOphthalmology Section, Providence VA Medical Center, 830 Chalkstone Avenue, Providence, RI, 02909, USA.ORCID 0000-0002-2305-6766 Wen-Chih WuCardiology Section, Medical Service, Providence VA Medical Center, 830 Chalkstone Avenue, Providence, RI, 02908, USA.ORCID 0000-0002-2834-2024 Saiju PyarajanCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, 150 S Huntington Avenue, Boston, MA, 02130, USA.
Hélène ChoquetDivision of Research, Kaiser Permanente Northern California (KPNC), 4480 Hacienda Drive, Pleasanton, CA, 94588, USA.ORCID 0000-0001-9839-8667 Sudha K IyengarCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0001-7488-250X Neal S PeacheyResearch Service, VA Northeast Ohio Healthcare System, 10701 East Boulevard, Cleveland, OH, 44106, USA.ORCID 0000-0002-4419-7226 Anat GalorSurgical and Research Services, Miami Veterans Administration Medical Center, 1201 NW 16th Street, Miami, FL, 33125, USA.ORCID 0000-0002-3026-6155 Funding
Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2MDifferentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain ImagingU01EY034686 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Eric Alan Moulton · 2022 to 2026
$4.7MTear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0MDry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9MNovel features of extraocular myosin regulationR01EY011377 · NEI · DUKE UNIVERSITY · PI SCHACHAT, FREDERICK H · 1996 to 2004
$1.4MBLRD VA I01 BX004557BLRD VA I01 BX004893BLRD VA IK6 BX005233CSRD VA I01 CX002015NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY011377NEI NIH HHS R01 EY026174NEI NIH HHS R61 EY032468NEI NIH HHS U01 EY034686RRD VA I21 RX003883
6 · The paper itselfAbstract
Dry eye disease (DED) affects up to 25% of the adult population, with chronic symptoms of pain and dryness often negatively impacting quality of life. The genetic architecture of DED is largely unknown. Here, we develop and validate an algorithm for DED in the Million Veteran Program using a combination of diagnosis codes and prescription records, resulting in 132,657 cases and 352,201 controls. In a multi-ancestry genome-wide association study, we identify ten significant loci in nine susceptibility regions with largely consistent effects across ancestries, including loci linked to synapse maintenance (
Indexed as
comorbiditiesdry eye diseasegenome-wide association studyheritability
Identifiers
PMID40166553
PMCPMC11957100
What OpenQuestion holds
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