Evidence map›Paper›PMID 40166508›Full record

ArticleCureus2025

Parkinsonism Hyperpyrexia Syndrome: A Rare Cause of Temperature Elevation.

Maria Margarida Rosado, Sara Campos, Nuno Bernardino Vieira

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Margarida RosadoInternal Medicine, Unidade Local de Saúde do Algarve - Hospital de Portimão, Portimão, PRT.
Sara CamposInternal Medicine, Unidade Local de Saúde do Algarve - Hospital de Portimão, Portimão, PRT.
Nuno Bernardino VieiraInternal Medicine, Unidade Local de Saúde do Algarve - Hospital de Portimão, Portimão, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fever is a common finding in hospitalized patients, and a noninfectious cause is present in up to half of cases. Parkinsonism hyperpyrexia syndrome is a rare and potentially fatal complication of Parkinson's disease, characterized by the presence of clinical features of neuroleptic malignant syndrome in patients who have reduced or completely discontinued antiparkinsonian medications. We report the case of a 63-year-old female patient with Parkinson's disease presenting with a sensorium alteration and noncompliance with her usual medication, parkinsonism, rhabdomyolysis, acute kidney injury, and transaminase elevation. Due to the persistence of the fever, despite resuming her usual antiparkinsonian medications, bromocriptine was initiated with a resolution of symptoms. We conclude that a thorough clinical history, with a drug compliance review, should be made to ensure a correct diagnosis and prompt treatment initiation.

Indexed as

bromocriptinedrug-induced feverfeverhyperthermiaparkinsonism hyperpyrexiaparkinson's disease

Identifiers

PMID40166508
PMCPMC11955575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.