Evidence map›Paper›PMID 40166381›Full record

ArticleMaterials today. Bio2025

Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer.

Xiongjie Zhu, Juanjuan Lei, Chao Jiang, Zhaobi Fang, Wenkai Zhang, Zhe Yang, Rui Guo, Rui Xu, Xiaoshan Hu

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiongjie ZhuDepartment of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.
Juanjuan LeiDepartment of Hepatobiliary Surgery, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.
Chao JiangDepartment of Cancer Center, The People's Hospital of Baoan Shenzhen, Guangdong, China.
Zhaobi FangDepartment of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Wenkai ZhangDepartment of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.
Zhe YangSouthern Medical University, Guangzhou, China.
Rui GuoKey Laboratory of Biomaterials Of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, China.
Rui XuDepartment of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaoshan HuDepartment of Medical Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most common malignant tumors in women, accounting for 7-10 % of all malignant tumors in the body. Second only to uterine cancer, it poses a significant threat to women's health. In this study, a two-dimensional material based on GO nanoparticles was designed to combine photothermal therapy (PTT) with chemotherapy for targeted treatment of breast cancer. Firstly, HPAA was grafted onto GO through an amide reaction after EDC/NHS activation. Secondly, RGD was attached to the amino group of HPAA. Finally, the chemotherapeutic drug doxorubicin was loaded through intermolecular interactions.

Indexed as

Breast cancerChemotherapyPhotothermal therapyTargetedTwo-dimensional

Identifiers

PMID40166381
PMCPMC11957798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.