Evidence map›Paper›PMID 40166379›Full record

ArticleMaterials today. Bio2025

Bioinspired hydrogel for sustained minocycline release: A superior periodontitis solution.

Shiyao Liu, Wenqian Zheng, Lina Wang, Yajie Zhang, Kang Feng, Yan Zhang, Haitao Yang, Yao Xiao, Chenxi Sun, Xiqiang Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shiyao LiuDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Wenqian ZhengDepartment of Pharmacy, Aerospace Center Hospital, 15 YuQuan Road, Beijing, 100049, PR China.
Lina WangJiangxi Provincial Key Laboratory of Flexible Electronics, Jiangxi Science and Technology Normal University, 605 FengLin Road, Nanchang, 330013, PR China.
Yajie ZhangDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Kang FengDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Yan ZhangDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Haitao YangDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Yao XiaoDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Chenxi SunJiangxi Provincial Key Laboratory of Flexible Electronics, Jiangxi Science and Technology Normal University, 605 FengLin Road, Nanchang, 330013, PR China.
Xiqiang LiuDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.
Baoyang LuJiangxi Provincial Key Laboratory of Flexible Electronics, Jiangxi Science and Technology Normal University, 605 FengLin Road, Nanchang, 330013, PR China.
Xuemin YinDepartment of Stomatology, Nanfang Hospital, Southern Medical University, 1023 ShaTai South Road, Guangzhou, 510515, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis treatment remains challenging due to the limitations of clinical medication therapies, including drug cytotoxicity, poor drug retention, immune imbalances, and epithelial barrier damage. Here, inspired by bioisosterism, we develop a dual-network hydrogel-based drug delivery system (M@PP) with materials structurally similar to minocycline (a commonly used medication). The M@PP hydrogel exhibits optimal mechanical strength and bioadhesion, ensuring sufficient drug retention inside periodontal pockets. The sustained release of minocycline, combined with the hydrogel's acidic microenvironment and the antioxidant functional groups, provides M@PP with excellent biocompatibility, potent antibacterial activity (98.1 % against

Indexed as

BioadhesiveDrug deliveryMinocyclineMultifunctional hydrogelsPeriodontal regenerationPeriodontitis

Identifiers

PMID40166379
PMCPMC11957788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.