Evidence map›Paper›PMID 40166354›Full record

ArticlebioRxiv : the preprint server for biology2025

PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinson's disease.

Claire Y Chiang, Neringa Pratuseviciute, Yu-En Lin, Ayan Adhikari, Wondwossen M Yeshaw, Chloe Flitton, Pemba L Sherpa, Francesca Tonelli, Irena Rektorova, Timothy Lynch and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Claire Y ChiangDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-0999-9856
Neringa PratuseviciuteMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee; Dundee, United Kingdom.ORCID 0000-0002-1124-8699
Yu-En LinDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-5848-5405
Ayan AdhikariDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-8525-3263
Wondwossen M YeshawDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-3134-3458
Chloe FlittonAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, USA.ORCID 0009-0005-2778-8381
Pemba L SherpaDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-4678-0001
Francesca TonelliAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, USA.ORCID 0000-0002-4600-6630
Irena RektorovaSchool of Medicine and St Anne's Hospital,1st Department of Neurology, Pekarska 53, Czech Republic.ORCID 0000-0002-5455-4573
Timothy LynchDepartment of Neurology, Dublin Neurological Institute, Dublin, Ireland.ORCID 0000-0002-2380-8737
Joanna SiudaŚląski Uniwersytet Medyczny w Katowicach, Katowice, Poland.ORCID 0000-0002-0340-660X
Monika Rudzińska-BarKrakowska Akademia im. Andrzeja Frycza Modrzewskiego, Kraków, Poland.
Oleksandr PulykUzhhorod Regional Center of Neurosurgery & Neurology, Uzhhorod, Ukraine.ORCID 0000-0002-8717-047X
Peter BauerCENTOGENE GmbH, Rostock, Germany.ORCID 0000-0001-9414-4555
Christian BeetzCENTOGENE GmbH, Rostock, Germany.ORCID 0000-0001-7061-2895
Dennis W DicksonMayo Clinic Florida, Department of Neuroscience, Jacksonville FL 32224, USA.ORCID 0000-0001-7189-7917
Owen A RossMayo Clinic Florida, Department of Neuroscience, Jacksonville FL 32224, USA.ORCID 0000-0003-4813-756X
Zbigniew K WszolekMayo Clinic Florida, Department of Neuroscience, Jacksonville FL 32224, USA.ORCID 0000-0001-5487-1053
Christine KleinInstitute of Neurogenetics, University of Lübeck, Germany.ORCID 0000-0003-2102-3431
Alexander ZimprichDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1668-5177
Dario R AlessiAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, USA.ORCID 0000-0002-2140-9185
Esther M SammlerAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, USA.ORCID 0000-0003-3218-7116
Suzanne R PfefferDepartment of Biochemistry, Stanford University School of Medicine; Stanford, USA.ORCID 0000-0002-6462-984X

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
NIGMS NIH HHS T32 GM007276
6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of Rab GTPases that regulate receptor trafficking; activating mutations in

Identifiers

PMID40166354
PMCPMC11957146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.