Evidence map›Paper›PMID 40166326›Full record

ArticlebioRxiv : the preprint server for biology2025

Emergence of ST3390: A non-pigmented HA-MRSA clone with enhanced virulence.

Emily A Felton, Mary-Elizabeth Jobson, Ariana M Virgillio, Joshua Alvior, Eleonora Cella, Amorce Lima, Deanna Becker, Suzanne Silbert, Taj Azarian, Kami Kim and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Emily A FeltonDepartment of Molecules Biosciences, University of South Florida, Tampa, FL, USA.
Mary-Elizabeth JobsonDepartment of Molecules Biosciences, University of South Florida, Tampa, FL, USA.
Ariana M VirgillioDivision of Infectious Disease and Internal Medicine, University of South Florida, Tampa, Florida, USA.
Joshua AlviorDivision of Infectious Disease and Internal Medicine, University of South Florida, Tampa, Florida, USA.
Eleonora CellaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Amorce LimaEsoteric Testing/R&D Laboratory, Tampa General Hospital, Tampa, Florida, USA.
Deanna BeckerEsoteric Testing/R&D Laboratory, Tampa General Hospital, Tampa, Florida, USA.
Suzanne SilbertEsoteric Testing/R&D Laboratory, Tampa General Hospital, Tampa, Florida, USA.
Taj AzarianBurnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.ORCID 0000-0002-8611-5241
Kami KimCenter for Antimicrobial Resistance, University of South Florida, Tampa, FL, USA.
Lindsey N ShawDepartment of Molecules Biosciences, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-0629-8990

Funding

The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
Dissecting the Influence of a C-Terminal Processing Protease on S. aureus PathogenesisR01AI157506 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI124458NIAID NIH HHS R01 AI157506
6 · The paper itself

Abstract

Background: One of the most successful and widely-distributed hospital-associated lineages of MRSA is CC5. These strains are known from widespread antibiotic resistance, but less severe disease than CA-MRSA counterparts. Recently, CC5 descendant lineages have appeared globally with hypervirulent properties. Methods: Herein we use genomic analyses to study the epidemiology of a rare CC5 MRSA sequence type, ST3390, circulating within Tampa General Hospital (TGH). We employ genetic tools alongside Results: To date, there have only been 50 recorded instances of infection caused by ST3390 globally, with 36 of those occurring at TGH. Genomic analysis of strains identified numerous Conclusions: This is the first study to characterize the pathogenicity and genomic architecture of the rare MRSA lineage ST3390. Our work provides a deeper understanding of the clonal expansion of CC5, and the wider diversification of

Indexed as

MRSAmupirocinStaphylococcus aureus

Identifiers

PMID40166326
PMCPMC11957030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.