Evidence map›Paper›PMID 40166235›Full record

ArticlebioRxiv : the preprint server for biology2025

Bacterial ubiquitin ligase engineered for small molecule and protein target identification.

James S Ye, Abir Majumdar, Brenden C Park, Miles H Black, Ting-Sung Hsieh, Adam Osinski, Kelly A Servage, Kartik Kulkarni, Jacinth Naidoo, Neal M Alto and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

James S YeDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abir MajumdarDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3516-5855
Brenden C ParkDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Miles H BlackDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2864-1710
Ting-Sung HsiehDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2792-0168
Adam OsinskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0010-0733
Kelly A ServageDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-7183-2865
Kartik KulkarniDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jacinth NaidooDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0009-0007-1087-8553
Neal M AltoDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Margaret M StrattonDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA.ORCID 0000-0003-2686-9022
Dominique AlfandariDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.ORCID 0000-0002-0557-1246
Joseph M ReadyDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1305-9581
Krzysztof PawłowskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5367-0935
Diana R TomchickDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7529-4643
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9735-4678

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Clyde Smith · 2020 to 2026
$43.3M
Breathing life into dead enzymesDP2GM137419 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2019 to 2020
$2.6M
Phosphatidylinositol 3-Phosphate in the Regulation of Autophagic Membrane RemodelingK99GM147532 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HSIEH, TING-SUNG · 2022 to 2023
$225k
NIGMS NIH HHS DP2 GM137419NIGMS NIH HHS K99 GM147532NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

The

Identifiers

PMID40166235
PMCPMC11957136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.