Evidence map›Paper›PMID 40166210›Full record

ArticlebioRxiv : the preprint server for biology2025

Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats.

Helene Tonnele, Denghui Chen, Felipe Morillo, Jorge Garcia-Calleja, Apurva S Chitre, Benjamin B Johnson, Thiago Missfeldt Sanches, Marc Jan Bonder, Antonio Gonzalez, Tomasz Kosciolek and 25 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Helene TonneleCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.ORCID 0000-0001-6015-0471
Denghui ChenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-6541-3418
Felipe MorilloCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.ORCID 0000-0001-5232-4312
Jorge Garcia-CallejaInstitute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-4614-4574
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1709-9214
Benjamin B JohnsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7269-5145
Thiago Missfeldt SanchesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6962-9569
Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-8431-3180
Antonio GonzalezDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Tomasz KosciolekDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9915-7387
Anthony M GeorgeClinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.
Wenyan HanDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Katie HollDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0009-0007-9166-7423
Aidan HorvathDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Keita IshiwariClinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-6190-2249
Christopher P KingDepartment of Psychology, University at Buffalo, NY, USA.ORCID 0000-0002-6641-237X
Alexander C LamparelliDepartment of Psychology, University at Buffalo, NY, USA.
Connor D MartinClinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.
Angel Garcia MartinezDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Alesa H NetzleyDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0171-3363
Jordan A TripiDepartment of Psychology, University at Buffalo, NY, USA.
Tengfei WangDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA.ORCID 0000-0003-3527-3394
Elena BoschInstitute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0003-2848-103X
Peter A DorisCenter for Human Genetics, Institute of Molecular Medicine, McGovern Medical School, University of Texas at Houston, TX, USA.ORCID 0000-0002-0565-7939
Oliver StegleEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-8818-7193
Hao ChenDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA.ORCID 0000-0002-2680-6921
Shelly B FlagelMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7309-9908
Paul J MeyerDepartment of Psychology, University at Buffalo, NY, USA.ORCID 0000-0001-5665-2292
Jerry B RichardsClinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.
Terry E RobinsonDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7861-3737
Leah C Solberg WoodsDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.ORCID 0000-0002-7943-798X
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3024-114X
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0975-9019
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3634-0747
Amelie BaudCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.ORCID 0000-0003-2448-0283

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
The role of structural variants and tandem repeats in substance abuse-related behavioral traitsU01DA051234 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GYMREK, MELISSA, PALMER, ABRAHAM A · 2021 to 2025
$3.5M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIDA NIH HHS P50 DA037844NIDA NIH HHS U01 DA051234NIH HHS S10 OD026929Wellcome Trust
6 · The paper itself

Abstract

The intestinal microbiome influences health and disease. Its composition is affected by host genetics and environmental exposures. Understanding host genetic effects is critical but challenging in humans, due to the difficulty of detecting, mapping and interpreting them. To address this, we analysed host genetic effects in four cohorts of outbred laboratory rats exposed to distinct but controlled environments. We found that polygenic host genetic effects were consistent across environments. We identified three replicated microbiome-associated loci, one of which involved a sialyltransferase gene and

Identifiers

PMID40166210
PMCPMC11957159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.