Evidence map›Paper›PMID 40166206›Full record

ArticlebioRxiv : the preprint server for biology2025

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing.

Sriram Vijayraghavan, Alessandra Ruggiero, Samuel Becker, Piotr Mieczkowski, George S Hanna, Mark T Hamann, Natalie Saini

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sriram VijayraghavanDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-8248-7833
Alessandra RuggieroDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Samuel BeckerDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Piotr MieczkowskiDepartment of Genetics, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2418-0096
George S HannaDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-7616-064X
Mark T HamannCollege of Pharmacy Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-3798-4002
Natalie SainiDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-1668-5417

Funding

Determining the factors that impact single stranded DNA mutagenesisR35GM151021 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Natalie Saini · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM151021
6 · The paper itself

Abstract

Methylglyoxal (MG) is a highly reactive aldehyde that is produced endogenously during metabolism and is derived from exogenous sources such as sugary food items and cigarette smoke. Unless detoxified by glyoxalases (Glo1 and Glo2), MG can readily react with all major biomolecules, including DNA and proteins, generating characteristic lesions and glycation-derived by- products. As a result, MG exposure has been linked to a variety of human diseases, including cancers. Prior studies show that MG can glycate DNA, preferentially on guanine residues, and cause DNA damage. However, the mutagenicity of MG is poorly understood

Identifiers

PMID40166206
PMCPMC11956917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.