ArticlebioRxiv : the preprint server for biology2025
The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sphingolipids play crucial roles in cell membrane structure and in multiple signaling pathways. Sphingolipid Highlights: RMDL isoforms detect varying ceramide levels to regulate SPT.HeLa cells, there is no compensation for the absence of the ORMDL isoform, neither at the total protein level nor at the mRNA level.
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