Evidence map›Paper›PMID 40166188›Full record

ArticlebioRxiv : the preprint server for biology2025

Stable hypermutators revealed by the genomic landscape of DNA repair genes among yeast species.

Carla Gonçalves, Jacob L Steenwyk, David C Rinker, Dana A Opulente, Abigail L LaBella, Marie-Claire Harrison, John F Wolters, Xiaofan Zhou, Xing-Xing Shen, Shay Covo and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Carla GonçalvesVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
Jacob L SteenwykVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
David C RinkerVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
Dana A OpulenteLaboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI 53726, USA.
Abigail L LaBellaVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
Marie-Claire HarrisonVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
John F WoltersLaboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI 53726, USA.
Xiaofan ZhouVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.ORCID 0000-0002-2879-6317
Xing-Xing ShenVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.
Shay CovoDepartment of Plant Pathology and Microbiology, Hebrew University of Jerusalem, Rehovot, Israel.
Marizeth GroenewaldWesterdijk Fungal Biodiversity Institute, 3584 Utrecht, The Netherlands.
Chris Todd HittingerLaboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0001-5088-7461
Antonis RokasVanderbilt University, Department of Biological Sciences, Nashville, TN 37235, United States of America.ORCID 0000-0002-7248-6551

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
NHGRI NIH HHS T32 HG002760NIAID NIH HHS R01 AI153356
6 · The paper itself

Abstract

Mutator phenotypes are short-lived due to the rapid accumulation of deleterious mutations. Yet, recent observations reveal that certain fungi can undergo prolonged accelerated evolution after losing DNA repair genes. Here, we surveyed 1,154 yeast genomes representing nearly all known yeast species of the subphylum Saccharomycotina to examine the relationship between reduced DNA repair repertoires and elevated evolutionary rates. We identified three distantly related lineages-encompassing 12% of species-with substantially reduced sets of DNA repair genes and the highest evolutionary rates in the entire subphylum. Two of these "faster-evolving lineages" (FELs)-a subclade within the order Pichiales and the

Indexed as

DNA repairGene losshorizontal gene transfermacroevolutionrapid evolutionyeast genome evolutionyeast pathogens

Identifiers

PMID40166188
PMCPMC11957042

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.