Evidence map›Paper›PMID 40166067›Full record

ArticleFrontiers in medicine2025

Lamellar keratoplasty using acellular porcine corneal stroma for the treatment of corneal ulcers.

Yiming Hu, Lan Zhang, Lei Wu, Yao Zhu, Li Wu, Chenye Li, Youyang Ruan, Yunwei Hu, Feifei Wang, Zhirong Lin and 1 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiming Hu *Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lan Zhang *Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lei WuDepartment of Ophthalmology, Tongcheng County People's Hospital, Xianning, China.
Yao ZhuDepartment of Ophthalmology, Xichang People's Hospital, Yichang, China.
Li WuOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Chenye LiOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Youyang RuanSchool of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yunwei HuOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Feifei WangOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhirong LinThe Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University Xiamen, Xiamen, China.
Qifang JinOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The study aimed to investigate the efficacy and safety of acellular porcine corneal stroma (APCS) for lamellar keratoplasty in the treatment of corneal ulcers. Methods: A total of 14 patients (14 eyes) diagnosed with corneal ulcers who underwent lamellar keratoplasty using acellular porcine corneal stroma at the Second Affiliated Hospital of Nanchang University between June 2016 and May 2017 were recruited and followed up for at least 12 months. Postoperative visual acuity, epithelial recovery, graft transparency, the recurrence rate of corneal ulcers, the rate of graft rejection, corneal neovascularization, graft infection, secondary glaucoma, and graft melting were examined and analyzed. Results: All 14 patients (100%) who underwent lamellar keratoplasty using acellular porcine corneal stroma successfully preserved the structure of their eyeballs. The visual acuity improved in 11 patients (78.5%). Graft rejection occurred in one patient (7.1%), while two patients (14.3%) developed recurrent corneal ulcers. Corneal vessel ingrowth was observed in seven patients (50%), and one patient (7.1%) developed pseudopterygium. The average time for complete epithelial recovery was 3-7 days. Conclusion: Lamellar keratoplasty using acellular porcine corneal stroma is an effective surgical alternative for the treatment of corneal ulcers.

Indexed as

acellular porcine corneal stromacorneal graftfungal corneal ulcerlaminar keratoplastyviral corneal ulcer

Identifiers

PMID40166067
PMCPMC11955584

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.