Evidence map›Paper›PMID 40166014›Full record

ArticleResearch square2025

TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size.

Khader Ghneim, Felipe Ten-Caten, Ana Carolina Santana, Muhammad Bilal Latif, Diego Andres Diaz Dinamarca, Tamara García-Salum, Perla Mariana Del Rio Estrada, Puja Sohal, Zachary Strongin, Justin Harper and 23 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Khader GhneimPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Felipe Ten-CatenPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0000-0001-7771-1490
Ana Carolina SantanaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Muhammad Bilal LatifPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Diego Andres Diaz DinamarcaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Tamara García-SalumPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Perla Mariana Del Rio EstradaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Puja SohalPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0009-0001-2147-5211
Zachary StronginDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Justin HarperDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6948-3501
Sherrie JeanDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Chelsea WallaceDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Robert BalderasBecton Dickinson, San Jose, CA, USA.ORCID 0000-0002-8734-8629
Jeffrey D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Gopalan RaghunathanDepartment of Discovery Biologics, Merck & Co. Inc., South San Francisco, CA, USA.
Eric RimmerDepartment of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co. Inc., South San Francisco, CA, USA.
Cinthia PastuskovaDepartment of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co. Inc., South San Francisco, CA, USA.
Guoxin WuDepartment of Quantitative Biosciences, Merck & Co. Inc., Rahway, NJ, USA.
Luca MicciDepartment of Discovery Oncology, Merck & Co., Inc., Boston, Massachusetts, USA.
Luiz Felipe Martins SiebenDepartment of Mathematics, Cleveland State University, Cleveland, OH, USA.
Pedro Cesar Lopes GerumDepartment of Mathematics, Cleveland State University, Cleveland, OH, USA.
Jessica Dos SantosDepartment of internal medicine, Radboudumc, Nijmegen, the Netherlands.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-2421-6052
Andre van der VenDepartment of internal medicine, Radboudumc, Nijmegen, the Netherlands.ORCID 0000-0003-1833-3391
Guido SilvestriPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0000-0001-6602-2470
Daria J HazudaDepartment of Quantitative Biosciences, Merck & Co. Inc., Rahway, NJ, USA.
Daniel M GormanDepartment of Discovery Biologics, Merck & Co. Inc., South San Francisco, CA, USA.
Bonnie J HowellDepartment of Quantitative Biosciences, Merck & Co. Inc., Rahway, NJ, USA.
Ashish A SharmaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Mirko PaiardiniPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0000-0002-7276-3600
Hugo SoudeynsPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
Susan Pereira RibeiroPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0000-0002-3127-3138
Rafick P SekalyPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.ORCID 0000-0002-7816-4828

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Reversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIVR37AI141258 · NIAID · EMORY UNIVERSITY · PI Rafick Pierre Sekaly · 2018 to 2026
$7.8M
Resource CoreP40OD028116 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2020 to 2026
$5.9M
NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INIAID NIH HHS R37 AI141258NIAID NIH HHS U24 AI126683NIAID NIH HHS UM1 AI164561NIH HHS P40 OD028116
6 · The paper itself

Abstract

Immunotherapeutic approaches to eliminate latently HIV-infected cells are focused on the adaptive immune system. Herein we provide mechanistic evidence for a molecular cascade characterized by epigenetic reprogramming of innate myeloid cells and CD4 T cells. The coordinate regulation and gene expression mediated by transcription factors (TFs) IRF3, IRF7, STAT1 and C/EBPβ

Identifiers

PMID40166014
PMCPMC11957188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.