Evidence map›Paper›PMID 40166008›Full record

ArticleResearch square2025

Evaluation of in-vivo and in-vitro binding property of a novel PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers.

Xiyan Rui, Yuzhou Ding, Nailian Zhang, Xinran Zhao, Chie Seki, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Jun Qian, Bin Ji and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xiyan RuiTongji University Affilliated Yangpu Hospital: Shanghai Yangpu District Central Hospital; Fudan university.
Yuzhou DingTongji University Affilliated Yangpu Hospital: Shanghai Yangpu District Central Hospital; Fudan university.
Nailian ZhangTongji University Affilliated Yangpu Hospital: Shanghai Yangpu District Central Hospital; Fudan university.
Xinran ZhaoTongji University Affilliated Yangpu Hospital: Shanghai Yangpu District Central Hospital; Fudan university.
Chie SekiAdvanced Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology.
Tomoteru YamasakiDepartment of Advanced Nuclear Medicine Sciences,Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology.
Masayuki FujinagaDepartment of Advanced Nuclear Medicine Sciences,Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology.
Ming-Rong ZhangDepartment of Advanced Nuclear Medicine Sciences,Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology.
Jun QianFudan University School of Pharmacy.
Bin JiFudan University School of Pharmacy.
Rong ZhouTongji University Affilliated Yangpu Hospital: Shanghai Yangpu District Central Hospital.ORCID 0000-0003-0004-8621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging biomarker for neuroinflammation or tumor-associated macrophages. However, existing positron emission tomography (PET) tracers for CSF1R imaging commonly are suffering from limited specificity or sensitivity. Results: We have performed Conclusions: These results suggest [

Indexed as

[11C]CPPC[11C]o-aminopyridyl alkynyl derivativeAutoradiographyColony-stimulating factor 1 receptor (CSF1R)Positron emission computed tomography (PET)

Identifiers

PMID40166008
PMCPMC11957209

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.