Evidence map›Paper›PMID 40166006›Full record

ArticleResearch square2025

Cardiovascular Dysfunction and Altered Lysosomal Signaling in a Murine Model of Acid Sphingomyelinase Deficiency.

Yun-Ting Wang, Alexandra K Moura, Rui Zuo, Kiana Roudbari, Jenny Z Hu, Saher A Khan, Zhengchao Wang, Yangping Shentu, Mi Wang, Pin-Lan Li and 3 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yun-Ting WangUniversity of Houston.
Alexandra K MouraUniversity of Houston.
Rui ZuoUniversity of Houston.
Kiana RoudbariUniversity of Houston.
Jenny Z HuUniversity of Houston.
Saher A KhanUniversity of Houston.
Zhengchao WangUniversity of Houston.
Yangping ShentuWenzhou Medical University.
Mi WangUniversity of Houston.
Pin-Lan LiVirginia Commonwealth University.
Jiukuan HaoUniversity of Houston.
Yang ZhangUniversity of Houston.ORCID 0000-0002-8338-3013
Xiang LiUniversity of Houston.

Funding

Lysosome Trafficking Dysregulation of Arterial Myocytes in AtherogenesisR01HL122937 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN, ZHANG, YANG · 2014 to 2024
$4.0M
Enhancer of zeste homolog 2-mediated epigenetic activation of acid sphingomyelinase in endothelial dysfunction during obesityR01HL150007 · NHLBI · UNIVERSITY OF HOUSTON · PI LI, XIANG · 2020 to 2024
$2.2M
NHLBI NIH HHS R01 HL122937NHLBI NIH HHS R01 HL150007
6 · The paper itself

Abstract

Niemann-Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disorder (LSD) caused by the deficiency of acid sphingomyelinase (ASMD), which is encoded by the

Indexed as

acid sphingomyelinase deficiencycardiac pathologycoronary microvascular dysfunctionlysosome storage disorderNiemann-Pick Diseasepericyte-to-myofibroblast transition

Identifiers

PMID40166006
PMCPMC11957194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.