Evidence map›Paper›PMID 40165968›Full record

ArticleFrontiers in immunology2025

Translation of bi-directional transcripts enhances MHC-I peptide diversity.

Filip Zavadil, Tomas Henek, Justine Habault, René Chemali, Maria Camila Tovar-Fernandez, Chrysoula Daskalogianni, Laurence Malbert-Colas, Lixiao Wang, Sivakumar Vadivel Gnanasundram, Borek Vojtesek and 3 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Filip Zavadil *RECAMO, Masaryk Memorial Cancer Institute, Brno, Czechia.
Tomas Henek *RECAMO, Masaryk Memorial Cancer Institute, Brno, Czechia.
Justine HabaultInserm UMRS1131, Institut de Génétique Moléculaire, Université Paris Cité, Hôpital St. Louis, Paris, France.
René ChemaliUMR 1015 Immunologie des tumeurs et immunothérapie contre le cancer, B2M, Gustave Roussy, Université Paris Sud, Villejuif, France.
Maria Camila Tovar-FernandezInserm UMRS1131, Institut de Génétique Moléculaire, Université Paris Cité, Hôpital St. Louis, Paris, France.
Chrysoula DaskalogianniInserm UMRS1131, Institut de Génétique Moléculaire, Université Paris Cité, Hôpital St. Louis, Paris, France.
Laurence Malbert-ColasInserm UMRS1131, Institut de Génétique Moléculaire, Université Paris Cité, Hôpital St. Louis, Paris, France.
Lixiao WangDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.
Sivakumar Vadivel GnanasundramDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.
Borek Vojtesek *RECAMO, Masaryk Memorial Cancer Institute, Brno, Czechia.
Lenka Hernychova *RECAMO, Masaryk Memorial Cancer Institute, Brno, Czechia.
Sebastien Apcher *UMR 1015 Immunologie des tumeurs et immunothérapie contre le cancer, B2M, Gustave Roussy, Université Paris Sud, Villejuif, France.
Robin Fahraeus *RECAMO, Masaryk Memorial Cancer Institute, Brno, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antisense transcripts play an important role in generating regulatory non-coding RNAs but whether these transcripts are also translated to generate functional peptides remains poorly understood. In this study, RNA sequencing and six-frame database generation were combined with mass spectrometry analysis of peptides isolated from polysomes to identify Nascent Pioneer Translation Products (Na-PTPs) originating from alternative reading frames of bi-directional transcripts. Two Na-PTP originating peptides derived from antisense strands stimulated CD8

Indexed as

CD8-Positive T-LymphocytesHistocompatibility Antigens Class IPeptidesProtein BiosynthesisRNA, AntisenseAntigen PresentationHumansLeukocytes, MononuclearLymphocyte ActivationHistocompatibility Antigens Class IPeptidesRNA, Antisensebi-directional transcriptsbi-directional translationMHC-I epitopePioneer Translation Productsreverse strand antigenic peptides

Identifiers

PMID40165968
PMCPMC11956742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.