Evidence map›Paper›PMID 40165962›Full record

ReviewFrontiers in immunology2025

Pemphigoid disease model systems for clinical translation.

Marvin Tigges, Sören Dräger, Ilaria Piccini, Katja Bieber, Artem Vorobyev, Janin Edelkamp, Marta Bertolini, Ralf J Ludwig

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marvin TiggesQIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.
Sören DrägerDepartment of Dermatology, University Medical Center of the State of Schleswig-Holstein (UKSH), Lübeck, Germany.
Ilaria PicciniQIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.
Katja BieberLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Artem VorobyevDepartment of Dermatology, University Medical Center of the State of Schleswig-Holstein (UKSH), Lübeck, Germany.
Janin EdelkampQIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.
Marta BertoliniQIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.
Ralf J LudwigQIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigoid diseases constitute a group of organ-specific autoimmune diseases characterized and caused by autoantibodies targeting autoantigens expressed in the skin and mucous membranes. Current therapeutic options are still based on unspecific immunosuppression that is associated with severe adverse events. Biologics, targeting the IL4-pathway or IgE are expected to change the treatment landscape of pemphigoid diseases. However, clinical studies demonstrated that targeting these pathways alone is most likely not sufficient to meet patient and healthcare partitioners expectations. Hence, model systems are needed to identify and validate novel therapeutic targets in pemphigoid diseases. These include pre-clinical animal models,

Indexed as

Pemphigoid, BullousTranslational Research, BiomedicalAnimalsAutoantibodiesAutoantigensDisease Models, AnimalHumansAutoantibodiesAutoantigensbullous pemphigoidmodel systemsmucous membrane pemphigoidpathogenesispemphigoid diseasestreatment

Identifiers

PMID40165962
PMCPMC11955494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.