Evidence map›Paper›PMID 40165949›Full record

ArticleFrontiers in immunology2025

Ankita Chakraborty, Nabarun Chandra Das, Parth Sarthi Sen Gupta, Saroj Kumar Panda, Malay Kumar Rana, Srinivasa Reddy Bonam, Jagadeesh Bayry, Suprabhat Mukherjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ankita ChakrabortyIntegrative Biochemistry and Immunology Laboratory (IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.
Nabarun Chandra DasIntegrative Biochemistry and Immunology Laboratory (IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.
Parth Sarthi Sen GuptaSchool of Bioscience and Bioengineering, D.Y. Patil International University, Pune, India.
Saroj Kumar PandaDepartment of Chemistry, Indian Institute of Science Education and Research, Berhampur, Odisha, India.
Malay Kumar RanaDepartment of Chemistry, Indian Institute of Science Education and Research, Berhampur, Odisha, India.
Srinivasa Reddy BonamVaccine Immunology Laboratory, Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
Jagadeesh BayryDepartment of Biological Sciences & Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala, India.
Suprabhat MukherjeeIntegrative Biochemistry and Immunology Laboratory (IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent emergence of zoonotic monkeypox virus (Mpox) in human has triggered the virologists to develop plausible preventive measures. Hitherto, our understanding on the mechanism of immunopathogenesis of Mpox infection is elusive. However, available experimental evidences suggest induction of inflammation as the main cause of pathogenesis. Toll-like receptors (TLRs) are critical in initiating and modulating the host immune response to pathogens. Inflammatory responses observed in various poxvirus infections have, in fact, been shown to be mediated through TLR activation. Therefore, by in silico approaches, this study seeks to identify the Mpox antigen(s) (MAg) that are most likely to interact with human cell-surface TLRs. The Mpox proteomics data available in UniProt database contain 174 protein sequences, among which 105 immunoreactive proteins were modeled for 3D structure and examined for comparative protein-protein interactions with the TLRs through molecular docking and molecular dynamics simulation. F14, an 8.28 kDa infective protein of Mpox, was found to exhibit strong binding affinity (ΔG=-12.5 Kcal mol

Indexed as

Antigens, ViralMonkeypox virusMpox, MonkeypoxToll-Like Receptor 1Toll-Like Receptor 2Viral ProteinsComputer SimulationHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingProtein MultimerizationAntigens, ViralLigandsTLR1 protein, humanTLR2 protein, humanToll-Like Receptor 1Toll-Like Receptor 2Viral Proteinsbioinformaticsemerging virus diseaseimmunopathogenesisin silico approachmolecular dynamics simulationmonkeypoxpathogenesistoll-like receptor

Identifiers

PMID40165949
PMCPMC11955672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.