Distribution of HLA-DRB1 Alleles in Patients With Antiphospholipid Syndrome and Their Association With Antiphospholipid Antibodies Presence and Damage Indexes.

Ewa Haladyj, Barbara Stypinska, Agata Matusiewicz, Marzena Olesinska, Agnieszka Paradowska-Gorycka

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Article in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Ewa HaladyjEli Lilly and Company, Indianapolis, USA.ORCID https://orcid.org/0000-0002-5677-6292

Barbara StypinskaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland.

Agata MatusiewiczDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland.

Marzena OlesinskaDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland.

Agnieszka Paradowska-GoryckaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid syndrome (APS) is frequently coexisting with systemic lupus erythematosus (SLE) and the knowledge on its genetic background is essential. The objective of this work was to assess distribution of human leukocyte antigen (HLA)-DRB1 alleles in patients with APS with or without SLE in the context of Polish population data. The study was performed in a group of 112 patients with APS and healthy subjects to assess the distribution of HLA-DRB1 alleles in patients with APS and their association with clinical characteristics of patients with APS-antiphospholipid antibodies (aPLs) presence and disease activity/damage indexes. The distribution of HLA-DRB1 alleles showed significant differences between patients with APS and healthy subjects. Allelic variant HLA-DRB1

Indexed as

AllelesAntibodies, AntiphospholipidAntiphospholipid SyndromeHLA-DRB1 ChainsAdultFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansLupus Erythematosus, SystemicMaleMiddle AgedPolandAntibodies, AntiphospholipidHLA-DRB1 Chainsantiphospholipid syndrome (APS)human leukocyte antigen (HLA)systemic lupus erythematosus (SLE)

Identifiers

PMID40165867

DOI10.1155/jimr/2827348

PMCPMC11957857

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