Evidence map›Paper›PMID 40165585›Full record

ReviewPhysiological reports2025

Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease.

Zhantao Yu, Kevin A Swift, Madeline A Hedges, Arianne L Theiss, Sarah F Andres

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhantao YuDivision of Gastroenterology and Hepatology, Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0003-1396-9833
Kevin A SwiftDepartment of Pediatrics, Pediatric GI Division, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Madeline A HedgesDepartment of Neonatology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Arianne L TheissDivision of Gastroenterology and Hepatology, Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado, USA.
Sarah F AndresDepartment of Pediatrics, Pediatric GI Division, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-7587-2637

Funding

Defining bioactivities of peptides released from human milk proteins in the preterm infant intestineR01HD109193 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Brian Scottoline · 2023 to 2026
$2.6M
The role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitisK01DK129401 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI Sarah Andres · 2022 to 2026
$873k
BLRD VA I01 BX005288Crohn's Colitis Foundation SRA 900820GI & Liver Innate Immune Program (GALIIP) at the University of Colorado AnschutzHHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD109193HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01DK129401NICHD NIH HHS R01 HD109193NIDDK NIH HHS K01 DK129401The Gerber FoundationThe Helmsley Charitable Trust 2505-08294The Knight Cancer InstituteVeteran's Affairs BLRD MERIT IBX005288
6 · The paper itself

Abstract

The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected to EVs and the gastrointestinal tract. We will address new and emerging roles for EVs derived from internal sources such as the pancreas and immune system and how these miniature messengers alter organismal health or the inflammatory response within the GI tract. We will examine what is known about external EVs from dietary and bacterial sources and the immense anti-inflammatory, immune-modulatory, and proliferative potential within these nano-sized information carriers. EV interactions with the intestinal and colonic epithelium and associated immune cells at homeostatic and disease states, such as necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) will also be covered. We will discuss how EVs are being leveraged as therapeutics or for drug delivery and conclude with a series of unanswered questions in the field.

Indexed as

Extracellular VesiclesGastrointestinal DiseasesGastrointestinal TractAnimalsHumansInflammatory Bowel DiseasesIntestinal Mucosabacteriaexosomeinflammationintestine

Identifiers

PMID40165585
PMCPMC11959161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.