Evidence map›Paper›PMID 40165528›Full record

Observational studyJournal of pediatric gastroenterology and nutrition2025

Prevalence and trend of anemia in children with inflammatory bowel disease: A national register-based cohort study.

Giulia D'Arcangelo, Marco Brecciaroli, Giulia Gagliostro, Dalila Auletta, Salvatore Pellegrino, Serena Arrigo, Francesco Graziano, Erasmo Miele, Maria Teresa Illiceto, Patrizia Alvisi and 10 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Giulia D'ArcangeloPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Marco BrecciaroliPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Giulia GagliostroPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Dalila AulettaPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Salvatore PellegrinoPediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital "G. Martino", Messina, Italy.
Serena ArrigoGastroenterology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Francesco GrazianoPediatric Unit, Villa Sofia Cervello Hospital, Palermo, Italy.
Erasmo MieleDepartment of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
Maria Teresa IllicetoUnit of Pediatric Gastroenterology and Endoscopy, Department of Pediatrics, "S. Spirito" Hospital of Pescara, Pescara, Italy.
Patrizia AlvisiPediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy.
Dario DililloDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Costantino De GiacomoDivision of Pediatrics, Department of Maternal and Child Health, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Paolo LionettiDepartment of Neurofarba, Meyer Children's Hospital, University of Florence, Florence, Italy.
Maria PastorePediatrics - IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo", Foggia, Italy.
Mara CananziUnit of Gastroenterology, Digestive Endoscopy, Hepatology and Care of the Child with Liver Transplantation, University Hospital of Padova, Padova, Italy.
Matteo BramuzzoInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Roberto PanceriPediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Lorenzo NorsaDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Marina AloiPediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-7404-4004
SIGENP IBD Working Group

Funding

None
6 · The paper itself

Abstract

objectivesWe determined the prevalence of anemia and its characteristics in children with newly diagnosed inflammatory bowel disease (IBD) and investigated its trend during follow-up.

methodsAn observational, multicenter cohort study of IBD children with anemia at the diagnosis enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition IBD registry. Data were collected at the diagnosis and at 1 year.

resultsFive hundred eighty-nine (295 Crohn's disease [CD] [50%] and 294 ulcerative colitis [UC]/IBD unclassified [IBDU] [50%]) of 1634 patients with IBD presented with anemia (36%). Anemia rate was higher in CD than in UC (39% vs. 33%, p = 0.009), and most patients had moderate anemia (55%). Children with CD had higher rates of mild anemia than UC (38% vs. 33%, p < 0.0001), while severe anemia was more common in UC (13% vs. 6%, p = 0.001). In CD, lower age at the diagnosis and lower albumin level correlated with anemia severity (p = 0.0007 and <0.0001, respectively). In UC, severe disease was more common in patients with severe anemia compared to those with mild and moderate anemia (20.6% vs. 43.6%, p = 0.01; 17% vs. 43.6%, p = 0.001). At 1 year, 99 children (22.9%) were persistently anemic and were characterized by a more severe disease compared to those who had resolved their anemia.

conclusionsMore than one third of IBD children present with anemia, most commonly moderate. Severe anemia is more common in UC compared to CD. One in four patients is still anemic after 1 year from the diagnosis, suggesting inadequate attention to the issue and the need for dedicated therapeutic management and careful monitoring.

Indexed as

AnemiaColitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAdolescentChildChild, PreschoolCohort StudiesFemaleFollow-Up StudiesHumansInfantItalyMalePrevalenceRegistriesanemia of chronic diseaseepidemiologyiron deficiency anemia

Identifiers

PMID40165528
PMCPMC12133643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.