Evidence map›Paper›PMID 40165524›Full record

ArticleBrain and behavior2025

The Evolution of Ischemia-Reperfusion Injury Research in Ischemic Stroke: Insights From a Two-Decade Bibliometric Analysis.

Hongyu Xu, Xinglin Lu, Rongxing Qin, Lingduo Shao, Li Chen

Abstract read
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hongyu XuDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinglin LuDepartment of Critical Care Medicine, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, China.
Rongxing QinDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lingduo ShaoDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li ChenDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0000-0002-9478-6432

Funding

Clinical Research "Climbing" Program of the First Affiliated Hospital of Guangxi Medical University (YYZS2021002)Guangxi Medical and Health Appropriate Technology Development and Application Project (S2021107)National Natural Science Foundation of China 82260367National Natural Science Foundation of China 82271371
6 · The paper itself

Abstract

backgroundIschemic stroke is a complex disease with high mortality and disability rates. Ischemia-reperfusion injury is a common aftermath. There have been significant advancements in understanding ischemia-reperfusion injury in ischemic stroke over the past two decades. This study aims to evaluate the current state of ischemia-reperfusion injury in ischemic stroke through bibliometric analysis, identifying key research areas and emerging trends.

methodsRelevant documents in the Web of Science Core Collection, SCI-Expanded from January 1, 2003, to December 31, 2023, were downloaded on July 10, 2024. Bibliometric analysis was performed using HistCite, VOSviewer, CiteSpace, and Bibliometrics online analysis platform.

resultsA total of 2179 research papers from 611 journals in 66 countries were included in this study. Among these papers, China emerged as the leading contributor of ischemia-reperfusion injury in ischemic stroke publications, with Capital Medical University standing out as the institution with the highest number of publications in this area. Y. Zhang was identified as the author with the most publications during the study period. Brain Research was found to be the most prolific journal for this research. The keywords "ferroptosis", "circular RNA", "polarization", and "fatty acid binding protein" represent the current hot spots of ischemia-reperfusion injury in ischemic stroke research.

conclusionThis bibliometric analysis offers the first thorough overview of hot spots and research trends in ischemia-reperfusion injury in ischemic stroke over the previous 21 years, providing researchers with new ideas in the field. "ferroptosis", "circular RNA", "polarization", and "fatty acid binding protein" may be the focus of future studies.

Indexed as

BibliometricsBiomedical ResearchIschemic StrokeReperfusion InjuryAnimalsHumansbibliometric analysishot spotsischemia‐reperfusion injuryischemic stroketrends

Identifiers

PMID40165524
PMCPMC11959154

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.