Evidence map›Paper›PMID 40165489›Full record

ArticleAnalytical chemistry2025

Examining Instrumental Factors Influencing the Performance of Data-Independent Acquisition Methods in Hydrogen/Deuterium Exchange Mass Spectrometry.

Frantisek Filandr, Morgan Hepburn, Vladimir Sarpe, D Alex Crowder, Maryam Hassannia, Stephen Coales, Yuqi Shi, Rosa Viner, Martin A Rossotti, Joey G Sheff and 2 more

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Frantisek FilandrDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Morgan HepburnDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0002-0611-4004
Vladimir SarpeDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.
D Alex CrowderDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Maryam HassanniaDepartment of Chemistry, University of Calgary, Calgary, AB T2N 4N1, Canada.
Stephen CoalesTrajan Scientific & Medical - Raleigh, Morrisville, North Carolina 27560, United States.
Yuqi ShiThermo Fisher Scientific, San Jose, California 95134, United States.
Rosa VinerThermo Fisher Scientific, San Jose, California 95134, United States.
Martin A RossottiHuman Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
Joey G SheffHuman Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.ORCID 0000-0002-9269-6863
Jamshid TanhaHuman Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
David C SchriemerDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0002-5202-1618

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6M
NCI NIH HHS P01 CA092584
6 · The paper itself

Abstract

Hydrogen/deuterium exchange mass spectrometry (HX-MS) is a method used to study solution-phase protein structure and dynamics. Despite its many applications, HX-MS is limited in throughput because manual data analysis is still the norm. We previously developed HX-MS

Indexed as

Hydrogen Deuterium Exchange-Mass SpectrometryHumansMass SpectrometryPeptidesSARS-CoV-2Spike Glycoprotein, CoronavirusPeptidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID40165489
PMCPMC12239244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.