Evidence map›Paper›PMID 40165279›Full record

ArticleOrphanet journal of rare diseases2025

Immunization coverage and timeliness of vaccination in young patients with inborn errors of metabolism: a French multicentric study.

Anne-Sophie Renous, Lena Damaj, Magali Gorce, Magalie Barth, Antoine Bedu, Elise Sacaze, Delphine Lamireau, Cécile Laroche-Raynaud, Laurent Pasquier, Zoha Maakaroun-Vermesse and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anne-Sophie RenousCentre de référence Maladies Métaboliques ToTeM, Service de Médecine Pédiatrique, Hôpital Clocheville, CHRU Tours, 49 Bd Béranger, 37 044 Tours Cedex 1, Tours, France.
Lena DamajCompetence Center for Inborn Errors of Metabolism, CHU Rennes, Rennes, France.
Magali GorceReference Center for Inborn Errors of Metabolism, CHU Toulouse, Toulouse, France.
Magalie BarthDepartment of Medical Genetics, CHU Angers, Angers, France.
Antoine BeduCompetence Center for Inborn Errors of Metabolism, CHU Limoges, Limoges, France.
Elise SacazeCompetence Center for Inborn Errors of Metabolism, CHU Brest, Brest, France.
Delphine LamireauCompetence Center for Inborn Errors of Metabolism, CHU Bordeaux, Bordeaux, France.
Cécile Laroche-RaynaudCompetence Center for Inborn Errors of Metabolism, CHU Limoges, Limoges, France.
Laurent PasquierCompetence Center for Inborn Errors of Metabolism, CHU Rennes, Rennes, France.
Zoha Maakaroun-VermesseVaccination Center, CHU Tours, Tours, France.
Marine TardieuCentre de référence Maladies Métaboliques ToTeM, Service de Médecine Pédiatrique, Hôpital Clocheville, CHRU Tours, 49 Bd Béranger, 37 044 Tours Cedex 1, Tours, France.
François LabartheCentre de référence Maladies Métaboliques ToTeM, Service de Médecine Pédiatrique, Hôpital Clocheville, CHRU Tours, 49 Bd Béranger, 37 044 Tours Cedex 1, Tours, France. labarthe@univ-tours.fr.ORCID http://orcid.org/0000-0001-9788-9667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInborn errors of metabolism (IEMs) are rare disorders that are heterogeneous in severity and clinical presentation. Patients with IEMs should receive the vaccination schedule recommended for the whole population, and specific vaccinations, such as the seasonal influenza vaccine, for the most vulnerable. The aim of this study was to evaluate vaccination coverage and timeliness in young patients with an IEM. PATIENTS &

methodsWe conducted a retrospective multicentric (7 centers) study between February 2021 and May 2022 evaluating vaccination coverage and delays in French young patients with an IEM according to the yearly French vaccination schedules published since 2002. The results were analyzed considering patient health conditions as stable or at risk (defined as cardiorespiratory failure or by an IEM with a serious risk of metabolic crisis).

resultsTwo hundred seventy-five patients were enrolled in this study. Among them, only 164 (60%) were up-to-date with the standard French vaccination schedule, and 229 (83%) had received at least one vaccine from this schedule late. The rate of delayed vaccination was significantly greater in the at-risk group than in the stable group for the main primaries and first booster doses of the DTaP-IPV-Hib vaccine and for the first MMR injection. Finally, only 30 to 35% of at-risk patients were vaccinated against influenza during the three previous winters.

conclusionYoung patients with an IEM had insufficient vaccination coverage with significant delays, exposing them to vaccine-preventable diseases, particularly at-risk patients with cardiorespiratory failure or a serious risk of metabolic crisis. Furthermore, only a few of the most vulnerable patients had received specific vaccinations, such as the influenza vaccine. Therefore, optimizing vaccination within the recommended schedule is crucial for this population of vulnerable children who have regular hospital follow-up.

Indexed as

Metabolism, Inborn ErrorsVaccinationVaccination CoverageAdolescentChildChild, PreschoolFemaleFranceHumansImmunization ScheduleInfantInfluenza VaccinesMaleRetrospective StudiesInfluenza VaccinesPreventionVaccination delayVaccination scheduleVaccineVulnerable patient

Identifiers

PMID40165279
PMCPMC11959845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.