ArticleItalian journal of pediatrics2025
Risk factors for bronchiolitis obliterans development in children after Mycoplasma pneumoniae pneumonia: a retrospective study of 981 patients.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Narrative Review of the Pathophysiology of Post-Infectious Bronchiolitis Obliterans.Biomolecules · 2026Review
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Early Risk Stratification for Subsequent Small Airway Dysfunction in Hospitalized Children withChildren (Basel, Switzerland) · 2026Article
- Pathogenesis and Risk Factors of Post-Infectious Bronchiolitis Obliterans in Children: A Focus on Adenovirus and Mycoplasma Infections.Pathogens (Basel, Switzerland) · 2026Review
- Immune dysregulation inFrontiers in immunology · 2026Review
- Comparison of Different Corticosteroid Regimens for RefractoryInfection and drug resistance · 2026Article
- A nursing perspective on bronchoscopic intervention strategies for children with macrolide-unresponsiveFrontiers in medicine · 2026Article
- Analysis of Risk Factors and Development of a Predictive Nomogram for Bronchiolitis Obliterans in Children With Severe Adenovirus Pneumonia: A Retrospective Study.Canadian respiratory journal · 2026Article
- Clinical characteristics ofTranslational pediatrics · 2025Article
- A machine learning-based predictive model for multilobar pulmonary consolidation induced by macrolide-resistantMicrobiology spectrum · 2025Article
- Macrolide-resistant Mycoplasma pneumoniae pneumonia in Chinese children: a retrospective study of clinical features and prognosis.Italian journal of pediatrics · 2025Article
- Immune activation and mucin dysregulation in pediatric refractoryFrontiers in cellular and infection microbiology · 2025Article
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6 authors.
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Abstract
backgroundBronchiolitis obliterans (BO) is a rare and severe chronic pulmonary condition in children following an injury to lower respiratory tract lesion. Mycoplasma pneumoniae (M. pneumoniae) is the second etiology of post-infectious bronchiolitis obliterans (PIBO). The aim of this study was to determine risk factors for PIBO development in children after M. pneumoniae pneumonia.
methodsThis retrospective study enrolled 981 children admitted to Beijing children's hospital due to M. pneumoniae pneumonia between January 2016 and December 2022. The medical records of the PIBO and non-PIBO groups, including demographic, clinical, radiologic, and laboratory data were analyzed by multivariate logistic regression to reveal PIBO development-associated risk factors.
resultsSeventy-two of the study patients developed PIBO after M. pneumoniae pneumonia. Multivariate analysis showed that large lobar consolidation (OR 4.06, 95% CI 1.18-14.03), diffuse bronchiolitis (OR 11.78, 95% CI 3.28-42.22), co-infection (OR 3.65, 95% CI 1.60-8.33), atopic conditions (OR 12.32, 95% CI 5.2-29.11), bronchial mucus plug (OR 2.48, 95% CI 1.10-5.58), CPR (OR 1.01, 95% CI 1.00-1.02), mechanical ventilation (OR 2.95, 95% CI 1.00-8.67), and duration of fever (OR 1.19, 95% CI 1.05-1.37) were significantly associated with development of PIBO after M. pneumoniae pneumonia.
conclusionsIn children with M. pneumoniae pneumonia, large lobar consolidation, diffuse bronchiolitis, co-infections, atopic conditions, bronchial mucus plug, CRP, mechanical ventilation, and duration of fever appeared as prominent independent risk factors for PIBO. Timely application of HRCT could provide a basis for the early prediction of PIBO development in children.
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