ArticleRadiation oncology (London, England)2025
Prognostic implications of tumor volume reduction during radiotherapy in locally advanced cervical cancer: a risk-stratified analysis.
Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Early tumor shrinkage correlates with final EBRT response in cervical cancer patients treated with MRI-guided radiotherapy.Clinical and translational radiation oncology · 2026Article
- Article
- Higher pre-treatment lymphocyte-to-monocyte ratio predicts better tumor shrinkage after external beam radiotherapy in locally advanced cervical cancer.Frontiers in oncology · 2026Article
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10 authors.
Funding
Abstract
backgroundThis study aimed to identify key risk factors in locally advanced cervical cancer (LACC) patients receiving radical radiotherapy and to evaluate the prognostic significance of MRI-determined tumor volume regression (TVR) among varying risk groups.
methodsWe retrospectively analyzed a cohort of 176 cervical cancer patients (stages IIA-IVA) treated with intensity-modulated radiotherapy from January 2012 to December 2020. Three-dimensional MRI scans were utilized to measure TVR and lymph node volume regression (NVR). Kaplan-Meier analysis was employed to assess overall survival (OS), progression-free survival (PFS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS). Prognostic factors were further analyzed using Cox proportional hazards models.
resultsA tumor TVR of ≥ 94% was significantly associated with improved 5-year overall survival (OS; 82.7% vs. 49.8%, p < 0.001) and progression-free survival (PFS; 82.5% vs. 51.1%, p < 0.001). Patients with TVR ≥ 94% also demonstrated superior LRFS and DMFS compared to those with TVR < 94% (p < 0.001 and p = 0.012, respectively). In the concurrent chemoradiotherapy (CCRT) subgroup, higher TVR correlated with better prognosis, whereas in patients receiving radiotherapy alone, an increased TVR did not significantly impact OS. Notably, the prognostic value of TVR was most evident in patients with CYFRA21-1 levels below 7.7 ng/ml. In the NVR ≥ 94% subgroup, OS, PFS, and LRFS were significantly better than in patients with NVR < 94% (p < 0.01), with a trend towards improved DMFS observed (p = 0.138).
conclusionTVR serves as a pivotal prognostic marker in LACC patients with CYFRA21-1 levels below 7.7 ng/ml undergoing CCRT. Additionally, within the lymph node metastasis subgroup, patients achieving a NVR of ≥ 94% demonstrated a notably improved prognosis.
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