Evidence map›Paper›PMID 40165107›Full record

ArticleBMC infectious diseases2025

Morphological variability of Escherichia coli colonizing human wounds: a case report.

Xuejin Wang, Hanyu Wang, Jing Zhang, Yonglu Huang, Yongning Wu, Yang Wang, Rong Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lung microbiota of raccoon dogs (Frontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuejin Wang *Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, China.
Hanyu Wang *Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Jing ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, China.
Yonglu HuangDepartment of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, China.
Yongning WuThe Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, Beijing, 100021, China.
Yang WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. wangyang@cau.edu.cn.
Rong ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, China. zhang-rong@zju.edu.cn.

Funding

National Key Research and Development Program of China 2022YFD1800400National Natural Science Foundation of China 22193064
6 · The paper itself

Abstract

backgroundEscherichia coli, known for its adaptability, can cause diverse infections. Morphological variants, such as smooth and mucoid forms, correspond to different infection capabilities and antibiotic resistance profiles. This report presents the isolation of two distinct E. coli strains, a smooth strain and a mucoid strain, from a single patient. CASE PRESENTATION: A 70-year-old woman with a leg wound and lung infection was found to have two E. coli strains: a mucoid strain from her wound and sputum and a smooth strain from her rectal swab. Whole-genome sequencing confirmed genetic similarity between the strains with minor SNPs linked to their morphological differences. Both strains were resistant to β-lactam and quinolone antibiotics, complicating treatment. The patient recovered following treatment with Piperacillin/Tazobactam and regular wound care.

conclusionThis case highlights E. coli's phenotypic plasticity within a single host, impacting infection management and antibiotic response. Understanding the genetic basis of such morphological changes could inform more effective treatment strategies.

Indexed as

Escherichia coliEscherichia coli InfectionsWound InfectionAgedAnti-Bacterial AgentsFemaleHumansMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial AgentsAntibiotic resistanceEscherichia coliMucoid morphologyPhenotypic plasticitySmooth morphologyWhole-genome sequencing

Identifiers

PMID40165107
PMCPMC11956493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.