Evidence map›Paper›PMID 40165063›Full record

ArticleBMC genomics2025

Dexamethasone-induced whitening of rabbit brown adipose tissue: leptin resistance and mitochondrial dysfunction.

Xiaoqin Tang, Beibei Zhang, Puhang Xie, Yanpei Wei, Yanbo Qiu, Xiaohua Yi, Ziru Zhang, Muzi She, Xiuzhu Sun, Shuhui Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoqin TangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Beibei ZhangCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Puhang XieCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Yanpei WeiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Yanbo QiuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Xiaohua YiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Ziru ZhangCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Muzi SheCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Xiuzhu SunCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. sunxiuzhu@nwafu.edu.cn.
Shuhui WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. wangshuhui@nwafu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch on the effects of exogenous glucocorticoids on brown adipose tissue (BAT) is crucial for understanding how these hormones can induce metabolic disorders such as obesity. In this study, we explored the effects of glucocorticoids, specifically dexamethasone (Dex), on the metabolic transformation of BAT to white adipose tissue (WAT).

resultsOur results indicate a significant whitening shift in BAT upon Dex treatment, characterized by increased lipid deposition, decreased mitochondrial density, a significant decline in cellular ATP content, and reduced expression of mitochondrial markers. We demonstrate the crucial role of leptin resistance in mediating mitochondrial function through the overexpression and inhibition of LEPR.

conclusionsOur results suggest the role of leptin resistance in regulating of mitochondrial biogenesis and energy metabolism in glucocorticoid-induced brown adipose whiteness.

Indexed as

Adipose Tissue, BrownDexamethasoneLeptinMitochondriaAdenosine TriphosphateAdipose Tissue, WhiteAnimalsEnergy MetabolismGlucocorticoidsRabbitsReceptors, LeptinAdenosine TriphosphateDexamethasoneGlucocorticoidsLeptinReceptors, LeptinBrown adipose tissue whiteningDexamethasoneMitochondrial dysfunction

Identifiers

PMID40165063
PMCPMC11959718

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.