Evidence map›Paper›PMID 40164999›Full record

ArticleGut microbes2025

The crystal structure of the toxin EspC from enteropathogenic

Akila U Pilapitiya, Lilian Hor, Jing Pan, Lakshmi C Wijeyewickrema, Robert N Pike, Denisse L Leyton, Jason J Paxman, Begoña Heras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Repurposing of Furin Inhibitors to Reduce PathogenicAntibiotics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akila U PilapitiyaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0001-9821-467X
Lilian HorDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0002-2967-0134
Jing PanDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.
Lakshmi C WijeyewickremaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0001-6084-4887
Robert N PikeDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0002-2083-0269
Denisse L LeytonResearch School of Biology, Australian National University, Canberra, Australia.ORCID 0000-0003-4808-9289
Jason J PaxmanDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0002-1418-5910
Begoña HerasDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.ORCID 0000-0003-3469-7988

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteropathogenic

Indexed as

Bacterial ToxinsEnteropathogenic Escherichia coliEscherichia coli ProteinsCrystallography, X-RayEscherichia coli InfectionsHumansIntestinal MucosaModels, MolecularProtein ConformationType III Secretion SystemsBacterial ToxinsEscherichia coli ProteinsEspC protein, E coliType III Secretion Systemsautotransporter proteinbacterial infectionsdiarrhoeaEnteropathogenic E. colisecretion systemserine proteasetoxins

Identifiers

PMID40164999
PMCPMC11970781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.