ArticleEJNMMI research2025
Utility of quantitative standardized uptake value from pre-operative bone SPECT/CT for predicting post-surgical MRONJ healing response.
Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Imaging-based stratification of marginal versus segmental mandibulectomy in MRONJ.Journal of bone and mineral metabolism · 2026Observational
- Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosis.Osteoporosis and sarcopenia · 2026Review
- Medication-related osteonecrosis of the jaw: an evidence-based 2025 position statement from a Korean multidisciplinary task force.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Review
- Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force.Endocrinology and metabolism (Seoul, Korea) · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundMedication-related osteonecrosis of the jaw (MRONJ) is a challenging condition often associated with long-term use of anti-resorptive medications. Accurate diagnosis is essential, but predicting the prognosis is particularly difficult due to the high likelihood of recurrence after surgery. This study assesses the utility of quantitative values from bone SPECT/CT as predictors of surgical outcomes in MRONJ patients. MATERIALS AND
methodsWe analyzed a cohort of 57 MRONJ patients who underwent surgical treatment. Preoperative bone SPECT/CT scans were used to obtain the maximal SUV (SUVmax) of MRONJ lesions and the ratio of the SUVmax to the mean SUV of a reference region (rSUVmax). Logistic regression analysis was performed to evaluate the relationship between preoperative SUVmax and rSUVmax and surgical outcomes, adjusting for confounders such as age, sex, diabetes, type of bone-modifying agent, MRONJ-affected sites, and stage.
resultsBoth SUVmax and rSUVmax values increased with the progression from MRONJ stage 1 to stage 3 and were higher in the No Resolution group compared to the Complete Resolution group. Multivariate logistic regression analysis revealed that higher rSUVmax values were significantly associated with poor surgical outcomes (OR, 1.51; 95% CI, 1.07-2.14), whereas SUVmax values were not significantly associated (OR, 1.05; 95% CI, 0.98-1.13). Preoperative MRONJ stages did not significantly predict MRONJ resolution.
conclusionrSUVmax from bone SPECT/CT may serve as a valuable prognostic tool for assessing MRONJ severity and predicting surgical outcomes. Incorporating rSUVmax measurements into clinical practice could enhance decision-making and improve patient management. CLINICAL
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