Evidence map›Paper›PMID 40164914›Full record

ArticleNature human behaviour2025

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.

Samantha G Malone, Christal N Davis, Zachary Piserchia, Michael R Setzer, Sylvanus Toikumo, Hang Zhou, Emma L Winterlind, Joel Gelernter, Amy Justice, Lorenzo Leggio and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Samantha G Malone *Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8498-4208
Christal N Davis *Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3974-5598
Zachary PiserchiaUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD, USA.
Michael R SetzerUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD, USA.
Sylvanus ToikumoMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6024-0693
Hang ZhouVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Emma L WinterlindUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD, USA.
Joel GelernterVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Amy JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0003-0139-5502
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Baltimore, MD, USA.
Christopher T RentschDepartment of Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1408-7907
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Joshua C GrayUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD, USA. Joshua.gray@usuhs.edu.ORCID http://orcid.org/0000-0002-5351-561X

Funding

Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
Leveraging genetic and electronic health records data to identify novel targets and drugs for treating alcoholR01AA030041 · NIAAA · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI GRAY, JOSHUA CHARLES · 2022 to 2025
$2.3M
NIAAA NIH HHS R01 AA030041NIAAA NIH HHS R01 AA030056U.S. Department of Defense (United States Department of Defense) HU0001-22-2-0066U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R01AA030041
6 · The paper itself

Abstract

Despite neurobiological overlap, alcohol use disorder (AUD) and body mass index (BMI) show minimal genetic correlation (r

Indexed as

AlcoholismBody Mass IndexBrainGenetic PleiotropyAdultFemaleGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritancePhenotypePolymorphism, Single Nucleotide

Identifiers

PMID40164914
PMCPMC13007225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.