Evidence map›Paper›PMID 40164900›Full record

SynthesisNeurosurgical review2025

A systematic review and meta-analysis of robot-assisted deep brain stimulation: comparative insights with conventional techniques.

Mohammad Dashtkoohi, Sara Ashtari, Pouria Delbari, Mohammad Mahdi Mehrabi, Amirmasoud Karimi, Mohammad Mahdi Kakoienejad, Alireza Soltani Khaboushan, Mohammad Amin Dabbagh Ohadi

Abstract readComparative StudyMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad DashtkoohiDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Sara AshtariDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Pouria DelbariDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Mahdi MehrabiDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Amirmasoud KarimiDepartment of Surgery, Alborz University of Medical Sciences, Alborz, Iran.
Mohammad Mahdi KakoienejadIran University of Medical Sciences, Tehran, Iran.
Alireza Soltani KhaboushanDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Amin Dabbagh OhadiDepartment of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran. Ohadi1377@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecent robotic-assisted surgical systems have shown promising efficiency and accuracy in brain surgeries. However, their application in deep brain stimulation (DBS) surgery remains limited.

methodsStudies from the Embase, Scopus, and Pubmed databases were included using a modified search string, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We extracted technical aspects of robotic-assisted DBS (RA-DBS) surgery, patient characteristics, accuracy, safety, and overall clinical results. We applied a random effects model for analysis. Heterogeneity was evaluated using Cochran's Q test and the I

resultsThe pooled mean radial error (RE) and Euclidean distance (3D-EE) in robotic surgeries were 1.04 mm (95% CI 0.93 to 1.15 mm) and 1.19 mm (95% CI: 0.94 - 1.45 mm). RA-DBS outcomes regarding RE were comparable to conventional stereotactic DBS (C-DBS) surgery (SMD: -0.56, 95% CI: -1.35 - 0.22, P-value: 0.16). Also, the difference in the rates of reported complications was insignificant (OR: 0.26, 95% CI: -0.64 - 1.15, P-value: 0.58). None of the frame-based or frameless (P-value: 0.36), the use of MER (P-value: 0.11), or the type of anesthesia (P-value: 0.27) showed significant differences. However, there was an insignificant lower RE trend in the studies that employed frame-based techniques, used general anesthesia, and did not utilize MER.

conclusionOur study shows an acceptable level of error associated with RA-DBS. We found that the accuracy and complication rates were comparable to C-DBS. Due to substantial heterogeneity in the pooled mean RE and 3D-EE, more studies with higher sample sizes are required to evaluate RA-DBS.

Indexed as

Deep Brain StimulationNeurosurgical ProceduresRobotic Surgical ProceduresHumansStereotaxic TechniquesDeep Brain StimulationMinimally Invasive ProceduresNeurosurgical ProceduresRobotic Surgical ProceduresSafetySystematic Review

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.