Evidence map›Paper›PMID 40164844›Full record

ArticleJournal of anesthesia2025

Brain activity during intraoperative general anesthesia using resting-state functional magnetic resonance imaging ~ Feasibility study ~.

Junji Wakabayashi, Yoshitetsu Oshiro, Shigeyuki Kan, Masaaki Kohta, Masaaki Taniguchi, Norihiko Obata, Masako Okada, Eiji Kohmura, Takashi Sasayama, Satoshi Mizobuchi

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Article in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Junji WakabayashiDepartment of Anesthesiology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, Zip Code: 650-0017, Japan. oo22ver@yahoo.co.jp.ORCID http://orcid.org/0009-0008-7779-6533
Yoshitetsu OshiroDepartment of Anesthesiology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, Zip Code: 650-0017, Japan.
Shigeyuki KanResearch Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan.
Masaaki KohtaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Masaaki TaniguchiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Norihiko ObataDepartment of Anesthesiology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, Zip Code: 650-0017, Japan.
Masako OkadaDepartment of Anesthesiology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, Zip Code: 650-0017, Japan.
Eiji KohmuraDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Takashi SasayamaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Satoshi MizobuchiDepartment of Anesthesiology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, Zip Code: 650-0017, Japan.

Funding

Japan Society for the Promotion of Science 19K18295
6 · The paper itself

Abstract

backgroundIn recent years, the effects of general anesthetics on the brain have been widely studied at the sedation level using resting-state functional magnetic resonance imaging (rs-fMRI). Most anesthesia protocols use a single agent, and changes in spontaneous brain activity are examined to show the characteristics of each anesthetic agent. However, no studies have used rs-fMRI to evaluate the effects of anesthesia during actual surgery. We examined the feasibility of evaluating the effects of general anesthesia with sevoflurane using rs-fMRI during neurosurgery.

methodsWe enrolled 20 adult patients scheduled for transsphenoidal surgery. We compared differences between before and during general anesthesia in terms of brain functional connectivity of the thalamus by seed-to-voxel correlation analysis and local neural activity using fractional amplitude of low-frequency fluctuations (fALFF) analysis. An exclusion mask was applied to exclude brain areas showing intraoperative spatial artifacts and correct for differences in the magnitude of intra- and preoperative head movements.

resultsWe analyzed 16 patients. Functional connectivity of the thalamus to the contralateral thalamus, bilateral caudate nucleus and globus pallidus were significantly decreased during anesthesia. The precuneus and posterior cingulate cortex showed significantly decreased fALFF values during anesthesia.

conclusionThese findings were consistent with previous studies and indicate the feasibility of intraoperative rs-fMRI during general anesthesia.

Indexed as

Anesthesia, GeneralBrainMagnetic Resonance ImagingAdultAgedAnesthetics, InhalationBrain MappingFeasibility StudiesFemaleHumansMaleMiddle AgedSevofluraneAnesthetics, InhalationSevofluraneFunctional connectivityFunctional MRIGeneral anesthesiaIntraoperative neurophysiological monitoringMR

Identifiers

PMID40164844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.