ArticleNature microbiology2025
Parasite and vector circadian clocks mediate efficient malaria transmission.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization.Nature microbiology · 2026Article
- Assessing the risk of malaria re-transmission in Anhui Province, China: an integration of spatiotemporal scan statistics and ecological niche modeling.BMC infectious diseases · 2026Article
- Circadian Biology in Parasites: Beyond Known Mechanisms.Annual review of microbiology · 2025Review
- Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts.Parasites & vectors · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Malaria transmission begins when Anopheles mosquitos deposit saliva and Plasmodium parasites during a bloodmeal. As Anopheles mosquitos are nocturnal, we investigated whether their salivary glands are under circadian control, anticipating bloodmeals and modulating parasite biology for host encounters. Here we show that approximately half of the mosquito salivary gland transcriptome, particularly genes essential for efficient bloodmeals such as anti-blood clotting factors, exhibits circadian expression. Furthermore, measuring haemoglobin levels, we demonstrate that mosquitos prefer to feed and ingest more blood at nighttime. Notably, we show a substantial subset of the salivary-gland-resident parasite transcriptome cycling throughout the day, indicating that this stage is not transcriptionally quiescent. Among the sporozoite genes undergoing rhythmic expression are those involved in parasite motility, potentially modulating the ability to initiate infection at different times of day. Our findings suggest a circadian tripartite relationship between the vector, parasite and mammalian host that together modulates malaria transmission.
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