Evidence map›Paper›PMID 40164770›Full record

ArticleNature aging2025

Invigorating discovery and clinical translation of aging biomarkers.

Erik Jacques, Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, Raghav Sehgal, Seth Paulson, Julian Reinhard, Jakob Träuble, Waylon J Hastings and 36 more

Abstract read
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Erik JacquesDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chiara HerzogBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0002-1572-498X
Kejun YingDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1791-6176
Alan TomusiakBuck Institute for Research on Aging, Novato, CA, USA.
Jessica KasamotoProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Raghav SehgalProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9387-1758
Seth PaulsonMethuselah Foundation.
Julian ReinhardEvotec SE.
Jakob TräubleDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Waylon J HastingsInstitute for Advancing Health Through Agriculture, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0003-0875-2568
Alexander TyshkovskiyDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6215-190X
Sara HäggBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0002-2452-1500
John C EarlsBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0002-8239-911X
Christian E BehrensBayer Consumer Health.ORCID http://orcid.org/0000-0002-8889-0292
Jessica Lasky-SuBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0001-6236-4705
Gavin ZhouRegenerative Bio Inc, Hangzhou, China.
Eric MorgenBioAge Labs, Richmond, CA, USA.
John S TsangCenter for Systems and Engineering Immunology, Departments of Immunobiology and Biomedical Engineering, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3186-3047
Riccardo E MarioniBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0003-4430-4260
Xiao-Jun MaAlamar Biosciences, Inc, Fremont, CA, USA.
Alexandra StolzingLoughborough University, Loughborough, UK.
Christin GloriosoNeuroAge Therapeutics.
Jonathan S GootenbergDepartment of Medicine, Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
Omar O AbudayyehGene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.
M Austin ArgentieriMassachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0242-853X
Raymond H MakDepartment of Radiation Oncology, Dana-Farber/Brigham Cancer Center, Boston, MA, USA.
Lynne S CoxDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5306-285X
Andrew S BrackAdvanced Research Projects Agency for Health (ARPA-H).
Gordan LaucGenos Glycoscience Research Laboratory, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID http://orcid.org/0000-0003-1840-9560
David FurmanBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0002-3654-9519
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9958-3987
Björn SchumacherInstitute for Genome Stability in Aging and Disease, University Hospital and University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6097-5238
Jamie N JusticeBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0003-2953-4404
Tina WoodsCollider Health.
David GobelMethuselah Foundation.
Viviana I PerezHevolution Foundation.
David A SinclairDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9936-436X
Andrea B MaierBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0001-7206-1724
Nir BarzilaiBiomarkers of Aging Consortium.
Michael P SnyderBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0003-0784-7987
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5893-0831
Steve HorvathBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0002-4110-3589
Luigi FerrucciBiomarkers of Aging Consortium.ORCID http://orcid.org/0000-0002-6273-1613
Jesse R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpoganik@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-3098-8550
Mahdi MoqriDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6675-0566
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0372-7016

Funding

2024 Biomarkers of Aging ConferenceR13AG092128 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI POGANIK, JESSE R · 2025 to 2025
$41k
NIA NIH HHS R13 AG092128U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG065403
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40164770
PMCPMC12991831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.