ArticleNature genetics2025
The complexity of tobacco smoke-induced mutagenesis in head and neck cancer.
Abstract read
In one paragraph
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Centralized processing of frozen tumor tissues for global cancer genomics.Nature protocols · 2026Review
- Identification and validation of a previously missed mutational signature in colorectal cancer.Nature communications · 2026Article
- Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV-Positive Head and Neck Carcinoma.Cancer science · 2026Article
- Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes.Cell biology and toxicology · 2026Article
- Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.International journal of oral science · 2026Article
- Tumour promotion through the lens of evolution.Nature · 2026Review
- Somatic mutations and clonal evolution in normal tissues and cancer development.Experimental & molecular medicine · 2026Review
- Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer.Molecular oncology · 2026Article
- From Diagnosis to Behaviour Change: Applying the Health Action Process Approach to Smoking Cessation After Head and Neck Cancer.Behavioral sciences (Basel, Switzerland) · 2026Article
- Gene Expression Profiling and Prognostic Significance of Nuclear and Membrane Progesterone Receptors in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2026Article
- Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions.Communications biology · 2026Article
- Incidence, mortality, and DALYs of global pharyngeal cancer: systematic analysis and projections Based on global burden of disease study 2021.Annals of medicine · 2025Article
- SPARKI: a tool for the statistical analysis of pathogen identification results.Bioinformatics (Oxford, England) · 2025Article
- Somatic mutation and selection at population scale.Nature · 2025Article
- Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats.bioRxiv : the preprint server for biology · 2025Article
- Article
- Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis.Research square · 2025Article
- Geographic and age-related variations in mutational processes in colorectal cancer.medRxiv : the preprint server for health sciences · 2025Article
- Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis.bioRxiv : the preprint server for biology · 2025Article
- Reducible burden of laryngeal cancer in men aged 50 and older attributable to smoking and alcohol use: insights from the global burden of disease study 2021.Frontiers in public health · 2025Article
Corrections and comments
- Update of
Authors and funding
46 authors.
Laura TorrensGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0002-3309-6200
Sarah MoodyCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-4904-1041
Ana Carolina de CarvalhoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Mariya KazachkovaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Behnoush Abedi-ArdekaniGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Saamin CheemaCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5297-2042
Sergey SenkinGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0001-5848-005X
Thomas CattiauxGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ricardo Cortez Cardoso PenhaGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Joshua R AtkinsCancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0821-1112
Valérie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Priscilia ChopardGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Christine CarreiraEvidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ammal AbbasiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5272-6207
Jingwei WangCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-0201-2369
Stephen FitzgeraldCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Calli LatimerCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Marcos Diaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0658-0467
David JonesCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Jon TeagueCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Felipe Ribeiro PintoBrazilian National Cancer Institute, Rio de Janeiro, Brazil.
Luiz Paulo KowalskiUniversity of São Paulo Medical School, São Paulo, Brazil.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.ORCID http://orcid.org/0000-0001-9381-1520
Fabiola GiudiciUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
José Carlos de OliveiraAssociação de Combate ao Câncer em Goiás Hospital Araújo Jorge, Goiânia, Brazil.
Pagona LagiouSchool of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Areti LagiouSchool of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Marta VilenskyInstituto de Oncología 'Angel Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
Dana MatesNational Institute of Public Health, Bucharest, Romania.
Ioan N MatesCarol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Lidia M ArantesBarretos Cancer Hospital, Barretos, Brazil.
Rui ReisBarretos Cancer Hospital, Barretos, Brazil.ORCID http://orcid.org/0000-0002-9639-7940
Jose Roberto V PodestaHospital Santa Rita de Cássia-Associação Feminina de Educação e Combate ao Câncer (AFECC), Vitória, Brazil.
Sandra V von ZeidlerPathology Department, Federal University of Espírito Santo, Vitória, Brazil.ORCID http://orcid.org/0000-0002-8897-5747
Ivana HolcatovaCharles University in Prague, 2nd Faculty of Medicine, IPHPM, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-1366-0337
Maria Paula CuradoA.C.Camargo Cancer Center, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8172-2483
Cristina CanovaUnit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padova, Italy.
Elenora FabianovaRegional Authority of Public Health, Banská Bystrica, Slovak Republic.
Paula A Rodríguez-UrregoHospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia.ORCID http://orcid.org/0000-0003-3693-7690
Laura HumphreysCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3596-4515
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Michael R StrattonCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6035-153X
Sandra PerdomoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. perdomos@iarc.who.int.ORCID http://orcid.org/0000-0001-7740-8141
Funding
Targeting Signaling Vulnerabilities for Oral Cancer PreventionR01DE026644 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jorge Silvio Gutkind, SCOTT M LIPPMAN · 2017 to 2026
$4.7MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MCancer Research UK (CRUK) C98/A24032EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 825771NCI NIH HHS R01 CA269919NCI NIH HHS U01 CA290479NIDCR NIH HHS R01 DE026644NIEHS NIH HHS R01 ES032547U.S. Department of Health and Human Services (U.S. Department of Health & Human Services) 1U01CA290479-01U.S. Department of Health and Human Services (U.S. Department of Health & Human Services) R01CA269919-01U.S. Department of Health and Human Services (U.S. Department of Health & Human Services) R01ES032547-01Wellcome TrustWorld Health Organization 001
Abstract
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). We explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC samples from eight countries. Six tobacco-associated mutational signatures were detected, including some not previously reported. Differences in HNC incidence between countries corresponded with differences in mutation burdens of tobacco-associated signatures, consistent with the dominant role of tobacco in HNC causation. Differences were found in the burden of tobacco-associated signatures between anatomical subsites, suggesting that tissue-specific factors modulate mutagenesis. We identified an association between tobacco smoking and alcohol-related signatures, indicating a combined effect of these exposures. Tobacco smoking was associated with differences in the mutational spectra, repertoire of driver mutations in cancer genes and patterns of copy number change. Our results demonstrate the multiple pathways by which tobacco smoke can influence the evolution of cancer cell clones.
Indexed as
Head and Neck NeoplasmsMutagenesisTobacco SmokingDNA Copy Number VariationsFemaleHumansMaleMutationSmokingWhole Genome Sequencing
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.