Evidence map›Paper›PMID 40164733›Full record

ArticleScientific reports2025

Altered internetwork functional connectivity and graph analysis of occipital regions in patients with chronic rhinosinusitis accompanied by olfactory dysfunction.

Hongmei Kuang, Shunda Hong, Yeyuan Chen, Hao Peng, Zihan Li, Yangyang Xie, Wanqing Zhou, Suhong Qin, Jing Ru, Jian Jiang

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Hongmei Kuang *Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Shunda Hong *Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Yeyuan ChenDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Hao PengDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Zihan LiDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Yangyang XieDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Wanqing ZhouDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Suhong QinDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Jing RuDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China.
Jian JiangDepartment of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330000, Jiangxi, China. ndyfy02072@ncu.edu.cn.

Funding

Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University and the Clinical Research Center For Medical Imaging In Jiangxi Province No.20223BCG74001the National Key Research and Development Program of China 2022YFC3602202the National Natural Science Foundation of China Grant No.81960313
6 · The paper itself

Abstract

This study assessed whole-brain functional connectivity and network graph theory indices in patients with chronic rhinosinusitis with (CRSwOD) and without (CRSsOD) olfactory dysfunction. We also analyzed correlations between the abnormal network metrics and clinical indices. We acquired resting-state functional magnetic resonance images from 31 patients with CRSsOD, 26 with CRSwOD, and 25 healthy controls (HCs). Functional connectivity was computed and graph theory metrics were evaluated based on the Dosenbach-160 Atlas; relationships between neuroimaging indicators and clinical scales were assessed using Pearson correlation analysis. The results showed that CRSsOD patients had 11 edges with greater strength than HCs, CRSwOD patients had 1 greater edge than HCs, and CRSsOD patients had 5 greater edges than CRSwOD patients. Nodal degree centrality and efficiency in the right posterior occipital region were significantly altered in patients with CRSsOD compared with those in CRSwOD and in HCs. Five and two edges correlated with clinical scales in patients with CRSsOD and CRSwOD, respectively, whereas no correlations in global and nodal indicators were found. These results imply that distinct brain network patterns, particularly in the occipital cortex, could be a valid neuroimaging marker for related diagnosis and prognosis of CRSsOD and CRSwOD patients, and contribute to our better understanding of the central neural mechanisms of CRSwOD, providing new ideas for the clinical management of CRSwOD.

Indexed as

Nerve NetOccipital LobeOlfaction DisordersRhinitisSinusitisAdultBrain MappingCase-Control StudiesChronic DiseaseConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRhinosinusitisChronic rhinosinusitisFunctional connectivityGraph analysisOccipital cortexOlfactory dysfunction

Identifiers

PMID40164733
PMCPMC11958658

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