Cholinergic tone abnormalities and relationships with smoking severity in human cigarette smokers: exploratory positron emission tomography study using [
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Scott J MoellerRenaissance School of Medicine at Stony Brook University, Stony Brook, NY, 11794, USA. scott.moeller@stonybrookmedicine.edu.ORCID http://orcid.org/0000-0002-4449-0844
Neurocircuitry of clinical insight predicting relapse outcomes in opioid addictionR01DA051420 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2020 to 2025
$2.9M
Neuromelanin MRI: A tool for non-invasive investigation of dopaminergic abnormalities in adolescent substance use.R01DA057268 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI Greg Perlman · 2023 to 2026
$2.9M
Neural, endocrine, and behavioral markers of psychosocial stress predicting drug use outcomes in human opioid addictionR01DA049733 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2021 to 2025
$2.6M
Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: a Multimodal MRI StudyK23MH115291 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI WEINSTEIN, JODI JAY · 2018 to 2024
$1.2M
Functional MRI in SchizophreniaR21MH126260 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DAI, WEIYING, HE, XIANG · 2022 to 2023
$467k
Neural and neurochemical correlates of metacognition impairment in opioid addictionR21DA048196 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2020 to 2021
$439k
Cholinergic transmission abnormalities associated with smoking behavior in humansR21DA051179 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOELLER, SCOTT J · 2020 to 2021
$439k
NIDA NIH HHS R01 DA049733NIDA NIH HHS R01 DA051420NIDA NIH HHS R01 DA057268NIDA NIH HHS R21 DA048196NIDA NIH HHS R21 DA051179NIMH NIH HHS K23 MH115291NIMH NIH HHS R21 MH126260U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH115291U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA049733U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA051420U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA057268U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R21DA048196U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R21DA051179
6 · The paper itself
Abstract
Nicotine acts on the brain cholinergic system to drive the rewarding effects of cigarettes and perpetuate smoking. Prior studies in human smokers have used positron emission tomography (PET) to characterize differences in postsynaptic nicotinic acetylcholine receptors (nAChRs). However, preclinical studies indicate that nicotine also modulates presynaptic cholinergic targets that have implications for transmission, including the vesicular acetylcholine transporter (VAChT). To date, there is a paucity of studies imaging presynaptic targets in human smokers. We conducted an initial PET neuroimaging study with [
Indexed as
Cigarette SmokingSmokingAdultBrainCorpus StriatumFemaleFluorine RadioisotopesHumansMaleMiddle AgedNicotinePositron-Emission TomographyReceptors, NicotinicSmokersVesicular Acetylcholine Transport ProteinsFluorine RadioisotopesNicotineReceptors, NicotinicVesicular Acetylcholine Transport Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cholinergic tone abnormalities and relationships with smoking severity in human cigarette smokers: exploratory positron emission tomography study using [ · full record | OpenQuestion