Evidence map›Paper›PMID 40164682›Full record

ArticleExperimental & molecular medicine2025

Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function.

Jeongin Seo, Ryeojin Ko, Minhee Kim, Jeongmin Seo, Hana Lee, Doyong Kim, Woojin Jeong, Han Sung Kim, Soo Young Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeongin SeoDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Ryeojin KoDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Minhee KimDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Jeongmin SeoDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Hana LeeDepartment of Biomedical Engineering, Yonsei University, Wonju, South Korea.
Doyong KimDepartment of Biomedical Engineering, Yonsei University, Wonju, South Korea.
Woojin JeongDepartment of Life Science, Ewha Womans University, Seoul, South Korea.ORCID http://orcid.org/0000-0003-1280-0067
Han Sung KimDepartment of Biomedical Engineering, Yonsei University, Wonju, South Korea.
Soo Young LeeDepartment of Life Science, Ewha Womans University, Seoul, South Korea. leesy@ewha.ac.kr.ORCID http://orcid.org/0000-0002-2590-3084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pim1 (proviral integration site for Moloney leukemia virus 1) protein is a serine/threonine kinase that is essential for cell proliferation, apoptosis and innate immune responses. Here we show that Pim1 promotes osteoclast resorptive function without affecting osteoclast numbers. Specifically, we found that mice lacking Pim1 (Pim1

Indexed as

Bone and BonesHomeostasisOsteoclastsProto-Oncogene Proteins c-pim-1AnimalsBone ResorptionMiceMice, Inbred C57BLMice, KnockoutSignal TransductionPim1 protein, mouseProto-Oncogene Proteins c-pim-1

Identifiers

PMID40164682
PMCPMC12046003

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.