Evidence map›Paper›PMID 40164674›Full record

ArticleScientific reports2025

Multi-scale modeling and simulation of skeletal muscles with different fatigue degrees based on microphysiology.

Monan Wang, Daixin Jin, Haibin Wang, Xinyi Xu, Siyuan Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monan WangCollege of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin, China. qqwmnan@163.com.
Daixin JinCollege of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin, China.
Haibin WangKey Laboratory of Medical Biomechanics and Materials of Heilongjiang Province, Harbin University of Science and Technology, Harbin, China.
Xinyi XuCollege of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin, China.
Siyuan ZhengCollege of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin, China.

Funding

National Natural Science Foundation of China,China 61972117
6 · The paper itself

Abstract

The ability for skeletal muscle to constantly generate force is limited by the muscle fatigue. The calcium ion plays a significant role of the cross-bridge cycle under fatigue conditions in the force generation of skeletal muscle. To uncover complicated fatigue behavior, we conducted a multi-scale model of skeletal muscle based on cellular biochemical events. We also parameterized our model to obtain the characteristics of the change of concentration of phosphate ions and phosphate compounds in the myoplasm. The results provided evidence that under different fatigue levels, the peak of muscle strength decreases with the increase of muscle fatigue, which proves that the synergistic effect of muscle filaments and phosphate will affect the circulation of calcium ions, thereby affecting muscle fatigue and generation of muscle force. We used our modeling approach to bring new insights into the effect of phosphate ions and synergistic effect of myofilaments.

Indexed as

Models, BiologicalMuscle FatigueMuscle, SkeletalAnimalsCalciumComputer SimulationHumansMuscle ContractionPhosphatesCalciumPhosphatesCalcium dynamicsMulti-scalePhosphate dynamicsSkeletal muscle

Identifiers

PMID40164674
PMCPMC11958672

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.