Evidence map›Paper›PMID 40164661›Full record

ArticleScientific reports2025

Carbon dot based dressing for therapy of chemically-induced cutaneous burns.

Halyna Kuznietsova, Arsen Ishchuk, Iryna Byelinska, Tetiana Lysenko, Volodymyr Melnytsky, Olexandr Ogloblya, Alexander Zaderko, Anna Kalinina, Denys Kryvosheiev, Vladimir Lysenko and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Halyna KuznietsovaInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine. biophyz@gmail.com.
Arsen IshchukInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.
Iryna ByelinskaInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.
Tetiana LysenkoInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.
Volodymyr MelnytskyInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.
Olexandr OgloblyaPhysics Department, Taras Shevchenko National University of Kyiv, Kyiv, 01033, Ukraine.
Alexander ZaderkoUniversite Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, UMR5306, Villeurbanne, 69100, France.
Anna KalininaVeterinary clinic Zoolux, Dmytrivska str. 39, Kyiv, 02000, Ukraine.
Denys KryvosheievInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.
Vladimir LysenkoUniversite Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, UMR5306, Villeurbanne, 69100, France.
Nataliia DziubenkoInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Volodymyrska str. 64/13, Kyiv, 01601, Ukraine.

Funding

EU Horizon 2020 Research and Innovation Staff Exchange Programme 101008159 "UNAT"Ministry of Education and Science of Ukraine 23BP07-02
6 · The paper itself

Abstract

Chemical burns are a significant concern in Ukraine, with a growing interest in new treatments. Carbon-based nanoparticles, due to their anti-inflammatory, antioxidant, and antibacterial properties, have shown promise for wound healing. This study aimed to evaluate the efficacy of carbon dots (CD) derived from citric acid and urea in promoting healing of both acidic- and alkali-induced burns in a rat model. The results indicated that acid-induced burns were slower to heal and exhibited more inflammation compared to alkali-induced burns with the same initial injury level. Daily application of CD dressings significantly reduced the burn area and inflammation in alkali-induced burns during the first week, i.e. accelerated burn healing process, although the treatment was less effective in acid burns. Both types of burns led to increased white blood cell counts, a left shift, and segmented neutrophils by day 7, signaling early acute inflammation. CD dressings notably reduced leukocytosis while preserving neutrophilia and lymphocyte release on days 7 and 14. Furthermore, CD treatment prevented post-burn anemia by maintaining erythrocyte integrity. The immune system's response and inflammation levels were consistent with the burn healing process and skin histopathology.Overall, CD accelerated healing, particularly in alkali burns, and had a systemic effect on immune and inflammatory responses.

Indexed as

BandagesBurns, ChemicalCarbonAnimalsCitric AcidDisease Models, AnimalMaleRatsRats, Sprague-DawleySkinUreaWound HealingCarbonCitric AcidUreaAcidic-induced burnAlkali-induced burnBlood cell inflammatory markersCarbon dotsSkin inflammation

Identifiers

PMID40164661
PMCPMC11958789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.