Evidence map›Paper›PMID 40164645›Full record

ArticleScientific reports2025

Ultrasound-based incidence of coarctation of the aorta in true and false positive fetuses.

Guihong Chen, Na Li, Zhenglun Alan Wei, Wei Zhao, Xijuan Guo, Yu Chen, Xuna Geng, Yuanyuan Peng, Bu-Lang Gao, Shuping Ge and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guihong ChenMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China. chenguihongn@sina.cn.
Na LiMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China.
Zhenglun Alan WeiDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, USA.
Wei ZhaoMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China.
Xijuan GuoMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China.
Yu ChenMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China.
Xuna GengMedical Ultrasound Department, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050000, China.
Yuanyuan PengPrenatal Diagnosis Center, Hebei Key Laboratory of Maternal and Fetal Medicine, The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.
Bu-Lang GaoCardiology Department, the people's Hospital of Shijiazhuang, No. 365, Jianhua South Street, Shijiazhuang, 050026, Hebei, China.
Shuping GeDepartment of Pediatric, and Adult Congenital Cardiology, Geisinger Heart and Vascular Institute, Geisinger Medical Center, Danville, USA.
Jie MiCardiology Department, the people's Hospital of Shijiazhuang, No. 365, Jianhua South Street, Shijiazhuang, 050026, Hebei, China. mmmjjj2015@163.com.

Funding

Shijiazhuang City Science and Technology Research and Development Plan 221200513
6 · The paper itself

Abstract

To investigate the incidence and significant ultrasound parameter changes of coarctation of the aorta (CoA) among fetuses with suspected CoA, pregnant women with suspected CoA fetuses on prenatal ultrasound examination were prospectively enrolled. The CoA presence was confirmed after birth by computed tomographic angiography, ultrasound, surgery or autopsies. The ultrasound parameters were analyzed. Among 133 fetuses with suspected CoA, 44 (33.1%) pregnant women with CoA fetuses were confirmed after delivery with an age range 20-41 (31.36 ± 4.73) years and a gestational age range 20.5-36.5 (27.35 ± 4.52) weeks, and 89 (66.9%) pregnant women were confirmed to have false-positive CoA fetuses with matched (P > 0.05) age (range 21-44 and mean 30.96 ± 4.59 years) and gestational age (range 19.6-34.1 and mean 28.22 ± 3.28 weeks). Ductus arteriosus (DA) tortuosity was present in significantly (P < 0.05) more false-positive CoA fetuses (15 or 16.85%) than in true CoA fetuses (1 or 2.27%), whereas significantly more intracardiac malformation [25 (56.82%) vs. 31 (34.83%)] and ventricular septal defect [10 (22.73%) vs. 6 (6.74%)] took place in true CoA fetuses than in the counterparts. Significant (P < 0.05) independent risk factors for CoA presence were sagittal view isthmic Z-score (odds ratio or OR 3.62 and 95% confidence interval or CI 2.06-7.15), coarctation shelf (OR 17.71 and 95% CI 5.52-56.78), ascending aortic diameter (OR 109.67 and 95% CI 3.03-21068.82), and DA velocity time integral (VTI) (OR 24.98 and 95% CI 1.26-759.94). The cutoff value and AUC were 0.40 and 0.912, respectively, for the fitted model, -4.24 and 0.779 for isthmus Z-score, 0.35 and 0.685 for the ascending aorta diameter, and 13.78 and 0.623 for DA VTI. In conclusion, many ultrasound parameters are significantly different in CoA fetuses, and sagittal view isthmus Z-score, coarctation shelf, ascending aortic diameter, DA VTI may independently affect CoA presence.

Indexed as

Aortic CoarctationFetusUltrasonography, PrenatalAdultFalse Positive ReactionsFemaleGestational AgeHumansIncidencePregnancyProspective StudiesYoung AdultCoarctation of the aortaFalse positiveFetusesRisk factorsUltrasound parameter

Identifiers

PMID40164645
PMCPMC11958706

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