ArticleNature communications2025
Photoredox cobalt-catalyzed asymmetric desymmetric reductive coupling of cyclobutenes with alkynes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Catalytic Transformations of Aza-Cyclobutenes, Fused Cyclobutenes, and Cyclobutenones.Chemical record (New York, N.Y.) · 2026Review
- Harnessing Photochemistry in Natural Product Synthesis: From Strategy to Applications.Journal of natural products · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Catalytic methods to couple alkynes and alkenes are highly valuable in synthetic chemistry. The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is particularly attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. However, the enantioselective transformations of this kind are less developed. The limited successful enantioselective examples are restricted to the use of electronically biased activated olefins as the coupling partners. Herein, we report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with alkynes to synthesize enantioenriched, synthetically important vinyl cyclobutanes via photoredox and cobalt dual catalysis. Excellent enantioselectivities, good diastereoselectivities and regioselectivities are obtained. Preliminary mechanistic studies suggest that Hantzsch ester is a better reducing reagent when used in combination with Et
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Registered trials
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