ArticleCell death discovery2025
Satb2 and Nr4a2 are required for the differentiation of cortical layer 6b.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Essential function of Nr4a2 in subicular development and social novelty.Journal of advanced research · 2026Article
- Gene expression profiling enables refined parcellation of cortical layers in the heterogeneous human cerebral cortex.Genome medicine · 2026Article
- Hippocampal Satb2 regulates the cognitive function of adult mice through pleiotrophin.Cell death & disease · 2026Article
- Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons.Neuroscience bulletin · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Cortical layer 6 is divided into two sublayers, and layer 6b is situated above the white matter with distinct architecture from layer 6a. Layer 6b arises from the subplate and contains the earliest born neurons in the development of cerebral cortex. Although great progress has been made in understanding the cortical morphogenesis, there is a dearth of knowledge regarding the molecular mechanisms governing the development of layer 6b neurons. Here we report that transcription factor special AT-rich binding protein 2 (Satb2) and nuclear receptor subfamily 4 group A member 2 (Nr4a2) are required for the normal differentiation layer 6b neurons. Upon conditional deletion of Satb2 in the cortex (Satb2
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