Evidence map›Paper›PMID 40164575›Full record

ArticleInternational journal of oral science2025

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription.

Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang and 1 more

Abstract read
In one paragraph

Article in International journal of oral science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhichun Jin *Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Hao Xu *Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Weiye ZhaoDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Kejia ZhangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Shengnan WuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Chuanjun ShuDepartment of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-1427-2037
Linlin ZhuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yan WangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Lin WangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. lw603@njmu.edu.cn.
Hanwen ZhangSchool of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. hanwenzhang@njmu.edu.cn.ORCID 0000-0002-7855-2564
Bin YanDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. byan@njmu.edu.cn.ORCID 0000-0001-9169-4615

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82071143National Natural Science Foundation of China (National Science Foundation of China) 82270361National Natural Science Foundation of China (National Science Foundation of China) 82371000
6 · The paper itself

Abstract

Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application. Numerous evidences support macrophages as the key immune cells during bone remodeling. Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1

Indexed as

Activating Transcription Factor 6MacrophagesTooth Movement TechniquesTumor Necrosis Factor-alphaAnimalsBlotting, WesternBone RemodelingFlow CytometryMiceActivating Transcription Factor 6Atf6 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID40164575
PMCPMC11958779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.