Evidence map›Paper›PMID 40164563›Full record

ArticleEpidemiology (Cambridge, Mass.)2025

Nicotine-Cannabis Transitions and Nicotine Abstinence Among United States Adults.

Dae-Hee Han, Adam M Leventhal, Andrew C Stokes, Janet E Audrain-McGovern, Sandrah P Eckel, Jessica Liu, Alyssa F Harlow

Abstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Methods for Vaping Cessation Among Young Adults in Southern California.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dae-Hee HanFrom the Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA.
Adam M LeventhalFrom the Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA.
Andrew C StokesDepartment of Global Health, Boston University School of Public Health, Boston, MA.
Janet E Audrain-McGovernDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA.
Sandrah P EckelFrom the Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA.
Jessica LiuDepartment of Pediatrics, Stanford University, Palo Alto, CA.
Alyssa F HarlowFrom the Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA.ORCID 0000-0001-6744-6988

Funding

USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Matthew Gesner Kirkpatrick · 2018 to 2026
$39.0M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
The Tobacco and Cannabis Retail Environment, Neighborhood Disadvantage, and Adolescent VapingK01DA058084 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Alyssa Fitzpatrick Harlow · 2023 to 2026
$752k
Effect of Product Characteristics on the Abuse Liability of Nicotine PouchesK99DA058241 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAN, DAE HEE · 2024 to 2025
$312k
NCI NIH HHS U54 CA180905NIDA NIH HHS K01 DA058084NIDA NIH HHS K24 DA048160NIDA NIH HHS K99 DA058241
6 · The paper itself

Abstract

backgroundPrior studies examining the association of cannabis use with nicotine abstinence did not distinguish between individuals co-using nicotine and cannabis versus those who switched from nicotine to exclusive cannabis use; these may have different effects on nicotine abstinence. We examined associations of cannabis use uptake with subsequent nicotine abstinence approximately 1 year later among adults using cigarettes and/or e-cigarettes.

methodsUsing six waves of the Population Assessment of Tobacco and Health Study (2013-2021), we assessed transitions from exclusive nicotine use prebaseline (time t ) to (1) exclusive cannabis use, (2) nicotine-cannabis co-use, (3) nonuse of both nicotine and cannabis, and (4) continued exclusive nicotine use at baseline ( t + 1) as exposure variables. Analyses examined associations with nicotine abstinence (from both cigarettes and e-cigarettes) at 1-year follow-up ( t + 2).

resultsAmong 8382 adults (19,618 observations) reporting exclusive nicotine use prebaseline, 1% transitioned to exclusive cannabis use, 9% to nicotine-cannabis co-use, and 9% to nonuse of both drugs; 81% were still using nicotine exclusively at baseline. Transition to nicotine-cannabis co-use (6%) versus exclusive nicotine use (10%) was inversely associated with nicotine abstinence at follow-up (adjusted relative risk [aRR] = 0.68; 95% confidence interval [CI] = 0.55, 0.83). Transition to exclusive cannabis use (72%) was positively associated with nicotine abstinence compared with continued exclusive nicotine use (10%; aRR = 4.66; 95% CI = 3.83, 5.67) and with similar nicotine abstinence at follow-up (72%) compared with nonuse of both drugs (65%; aRR=0.98; 95% CI = 0.81, 1.18).

conclusionCo-use of nicotine and cannabis was associated with lower nicotine abstinence. Switching to exclusive cannabis use was associated with similar or greater nicotine abstinence.

Indexed as

Marijuana SmokingNicotineSmoking CessationAdultElectronic Nicotine Delivery SystemsFemaleHumansMaleMiddle AgedUnited StatesYoung AdultNicotineCigarettesE-cigarettesNicotine abstinenceNicotine–cannabis use transitionPolyuse of nicotine and cannabis

Identifiers

PMID40164563
PMCPMC13267841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.